Differences in Types and Incidence of Neoplasms in Wistar Han and Sprague-Dawley Rats

A substantial quantity of data on Sprague-Dawley (SD) and Hannover Wistar rats strains have been published concerning their source, diet, and housing conditions, as well as the incidences of nonneoplastic lesions and neoplasms observed in different laboratories. Differences between the commonly used...

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Bibliographic Details
Published in:Toxicologic pathology 2017-01, Vol.45 (1), p.64-75
Main Author: Weber, Klaus
Format: Article
Language:English
Subjects:
Animals
Carcinogenicity Tests - veterinary
Female
Incidence
Male
Neoplasms - epidemiology
Neoplasms - etiology
Neoplasms - veterinary
Organ Specificity
Rats
Rats, Sprague-Dawley
Rats, Wistar
Species Specificity
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Summary:A substantial quantity of data on Sprague-Dawley (SD) and Hannover Wistar rats strains have been published concerning their source, diet, and housing conditions, as well as the incidences of nonneoplastic lesions and neoplasms observed in different laboratories. Differences between the commonly used rat strains provided by different breeders (i.e., CD (SD) vs. Harlan Sprague-Dawley strain or Crl: WI(Han) vs. Wistar Hannover (Han)–derived strain, continued breeding by RCC Ltd., Switzerland, thereafter continued breeding by Harlan) may include, but are not limited to, body weight, incidence, and onset of major nonneoplastic lesions and neoplasms, and these can impact the development of a nonclinical safety program. Fisher 344 (F344) and SD rat strains generally have the highest tumor incidences, exceeding that in Wistar rats. Certain tumors are more commonly observed in one strain, and for some, the difference in incidence may be so significant that the tumor may even be considered characteristic for a specific strain (e.g., thymoma in Wistar and amphophilic renal adenoma in SD).
ISSN:0192-6233
1533-1601
DOI:10.1177/0192623316672075