Differences in Types and Incidence of Neoplasms in Wistar Han and Sprague-Dawley Rats

A substantial quantity of data on Sprague-Dawley (SD) and Hannover Wistar rats strains have been published concerning their source, diet, and housing conditions, as well as the incidences of nonneoplastic lesions and neoplasms observed in different laboratories. Differences between the commonly used...

Full description

Saved in:
Bibliographic Details
Published in:Toxicologic pathology 2017-01, Vol.45 (1), p.64-75
Main Author: Weber, Klaus
Format: Article
Language:English
Subjects:
Animals
Carcinogenicity Tests - veterinary
Female
Incidence
Male
Neoplasms - epidemiology
Neoplasms - etiology
Neoplasms - veterinary
Organ Specificity
Rats
Rats, Sprague-Dawley
Rats, Wistar
Species Specificity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c478t-c4ada3df9641b2f121e7e113f74c0d284ef44bf09bb32385740ecc6895807d6d3
cites cdi_FETCH-LOGICAL-c478t-c4ada3df9641b2f121e7e113f74c0d284ef44bf09bb32385740ecc6895807d6d3
container_end_page 75
container_issue 1
container_start_page 64
container_title Toxicologic pathology
container_volume 45
creator Weber, Klaus
description A substantial quantity of data on Sprague-Dawley (SD) and Hannover Wistar rats strains have been published concerning their source, diet, and housing conditions, as well as the incidences of nonneoplastic lesions and neoplasms observed in different laboratories. Differences between the commonly used rat strains provided by different breeders (i.e., CD (SD) vs. Harlan Sprague-Dawley strain or Crl: WI(Han) vs. Wistar Hannover (Han)–derived strain, continued breeding by RCC Ltd., Switzerland, thereafter continued breeding by Harlan) may include, but are not limited to, body weight, incidence, and onset of major nonneoplastic lesions and neoplasms, and these can impact the development of a nonclinical safety program. Fisher 344 (F344) and SD rat strains generally have the highest tumor incidences, exceeding that in Wistar rats. Certain tumors are more commonly observed in one strain, and for some, the difference in incidence may be so significant that the tumor may even be considered characteristic for a specific strain (e.g., thymoma in Wistar and amphophilic renal adenoma in SD).
doi_str_mv 10.1177/0192623316672075
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1868306086</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_0192623316672075</sage_id><sourcerecordid>1868306086</sourcerecordid><originalsourceid>FETCH-LOGICAL-c478t-c4ada3df9641b2f121e7e113f74c0d284ef44bf09bb32385740ecc6895807d6d3</originalsourceid><addsrcrecordid>eNqNkM1Lw0AQxRdRbK3ePUmOXqI72WR3c5T60UJR0BaPYZOdLSn5cjdB-t-btNWDIHiZGeb93js8Qi6B3gAIcUshDnjAGHAuAiqiIzKGiDEfOIVjMh5kf9BH5My5DaUgIaSnZBRIyqWM2Zis7nNj0GKVofPyyltum_5QlfbmVZbr4e_VxnvGuimUK3fMe-5aZb2ZqnbgW2PVukP_Xn0WuPVeVevOyYlRhcOLw56Q1ePDcjrzFy9P8-ndws9CIdt-Kq2YNjEPIQ0MBIACAZgRYUZ1IEM0YZgaGqcpC5iMREgxy7iMI0mF5ppNyPU-t7H1R4euTcrcZVgUqsK6cwlILhnlVPJ_oJFgok-OepTu0czWzlk0SWPzUtltAjQZek9-995brg7pXVqi_jF8F90D_h5wao3Jpu5s1Rfzd-AXDX-Icw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1857379585</pqid></control><display><type>article</type><title>Differences in Types and Incidence of Neoplasms in Wistar Han and Sprague-Dawley Rats</title><source>Sage Journals Online</source><creator>Weber, Klaus</creator><creatorcontrib>Weber, Klaus</creatorcontrib><description>A substantial quantity of data on Sprague-Dawley (SD) and Hannover Wistar rats strains have been published concerning their source, diet, and housing conditions, as well as the incidences of nonneoplastic lesions and neoplasms observed in different laboratories. Differences between the commonly used rat strains provided by different breeders (i.e., CD (SD) vs. Harlan Sprague-Dawley strain or Crl: WI(Han) vs. Wistar Hannover (Han)–derived strain, continued breeding by RCC Ltd., Switzerland, thereafter continued breeding by Harlan) may include, but are not limited to, body weight, incidence, and onset of major nonneoplastic lesions and neoplasms, and these can impact the development of a nonclinical safety program. Fisher 344 (F344) and SD rat strains generally have the highest tumor incidences, exceeding that in Wistar rats. Certain tumors are more commonly observed in one strain, and for some, the difference in incidence may be so significant that the tumor may even be considered characteristic for a specific strain (e.g., thymoma in Wistar and amphophilic renal adenoma in SD).</description><identifier>ISSN: 0192-6233</identifier><identifier>EISSN: 1533-1601</identifier><identifier>DOI: 10.1177/0192623316672075</identifier><identifier>PMID: 28068893</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Animals ; Carcinogenicity Tests - veterinary ; Female ; Incidence ; Male ; Neoplasms - epidemiology ; Neoplasms - etiology ; Neoplasms - veterinary ; Organ Specificity ; Rats ; Rats, Sprague-Dawley ; Rats, Wistar ; Species Specificity</subject><ispartof>Toxicologic pathology, 2017-01, Vol.45 (1), p.64-75</ispartof><rights>The Author(s) 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-c4ada3df9641b2f121e7e113f74c0d284ef44bf09bb32385740ecc6895807d6d3</citedby><cites>FETCH-LOGICAL-c478t-c4ada3df9641b2f121e7e113f74c0d284ef44bf09bb32385740ecc6895807d6d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925,79364</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28068893$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Weber, Klaus</creatorcontrib><title>Differences in Types and Incidence of Neoplasms in Wistar Han and Sprague-Dawley Rats</title><title>Toxicologic pathology</title><addtitle>Toxicol Pathol</addtitle><description>A substantial quantity of data on Sprague-Dawley (SD) and Hannover Wistar rats strains have been published concerning their source, diet, and housing conditions, as well as the incidences of nonneoplastic lesions and neoplasms observed in different laboratories. Differences between the commonly used rat strains provided by different breeders (i.e., CD (SD) vs. Harlan Sprague-Dawley strain or Crl: WI(Han) vs. Wistar Hannover (Han)–derived strain, continued breeding by RCC Ltd., Switzerland, thereafter continued breeding by Harlan) may include, but are not limited to, body weight, incidence, and onset of major nonneoplastic lesions and neoplasms, and these can impact the development of a nonclinical safety program. Fisher 344 (F344) and SD rat strains generally have the highest tumor incidences, exceeding that in Wistar rats. Certain tumors are more commonly observed in one strain, and for some, the difference in incidence may be so significant that the tumor may even be considered characteristic for a specific strain (e.g., thymoma in Wistar and amphophilic renal adenoma in SD).</description><subject>Animals</subject><subject>Carcinogenicity Tests - veterinary</subject><subject>Female</subject><subject>Incidence</subject><subject>Male</subject><subject>Neoplasms - epidemiology</subject><subject>Neoplasms - etiology</subject><subject>Neoplasms - veterinary</subject><subject>Organ Specificity</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Rats, Wistar</subject><subject>Species Specificity</subject><issn>0192-6233</issn><issn>1533-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqNkM1Lw0AQxRdRbK3ePUmOXqI72WR3c5T60UJR0BaPYZOdLSn5cjdB-t-btNWDIHiZGeb93js8Qi6B3gAIcUshDnjAGHAuAiqiIzKGiDEfOIVjMh5kf9BH5My5DaUgIaSnZBRIyqWM2Zis7nNj0GKVofPyyltum_5QlfbmVZbr4e_VxnvGuimUK3fMe-5aZb2ZqnbgW2PVukP_Xn0WuPVeVevOyYlRhcOLw56Q1ePDcjrzFy9P8-ndws9CIdt-Kq2YNjEPIQ0MBIACAZgRYUZ1IEM0YZgaGqcpC5iMREgxy7iMI0mF5ppNyPU-t7H1R4euTcrcZVgUqsK6cwlILhnlVPJ_oJFgok-OepTu0czWzlk0SWPzUtltAjQZek9-995brg7pXVqi_jF8F90D_h5wao3Jpu5s1Rfzd-AXDX-Icw</recordid><startdate>201701</startdate><enddate>201701</enddate><creator>Weber, Klaus</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>201701</creationdate><title>Differences in Types and Incidence of Neoplasms in Wistar Han and Sprague-Dawley Rats</title><author>Weber, Klaus</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-c4ada3df9641b2f121e7e113f74c0d284ef44bf09bb32385740ecc6895807d6d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Carcinogenicity Tests - veterinary</topic><topic>Female</topic><topic>Incidence</topic><topic>Male</topic><topic>Neoplasms - epidemiology</topic><topic>Neoplasms - etiology</topic><topic>Neoplasms - veterinary</topic><topic>Organ Specificity</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Rats, Wistar</topic><topic>Species Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Weber, Klaus</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Toxicologic pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weber, Klaus</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differences in Types and Incidence of Neoplasms in Wistar Han and Sprague-Dawley Rats</atitle><jtitle>Toxicologic pathology</jtitle><addtitle>Toxicol Pathol</addtitle><date>2017-01</date><risdate>2017</risdate><volume>45</volume><issue>1</issue><spage>64</spage><epage>75</epage><pages>64-75</pages><issn>0192-6233</issn><eissn>1533-1601</eissn><abstract>A substantial quantity of data on Sprague-Dawley (SD) and Hannover Wistar rats strains have been published concerning their source, diet, and housing conditions, as well as the incidences of nonneoplastic lesions and neoplasms observed in different laboratories. Differences between the commonly used rat strains provided by different breeders (i.e., CD (SD) vs. Harlan Sprague-Dawley strain or Crl: WI(Han) vs. Wistar Hannover (Han)–derived strain, continued breeding by RCC Ltd., Switzerland, thereafter continued breeding by Harlan) may include, but are not limited to, body weight, incidence, and onset of major nonneoplastic lesions and neoplasms, and these can impact the development of a nonclinical safety program. Fisher 344 (F344) and SD rat strains generally have the highest tumor incidences, exceeding that in Wistar rats. Certain tumors are more commonly observed in one strain, and for some, the difference in incidence may be so significant that the tumor may even be considered characteristic for a specific strain (e.g., thymoma in Wistar and amphophilic renal adenoma in SD).</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>28068893</pmid><doi>10.1177/0192623316672075</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0192-6233
ispartof Toxicologic pathology, 2017-01, Vol.45 (1), p.64-75
issn 0192-6233
1533-1601
language eng
recordid cdi_proquest_miscellaneous_1868306086
source Sage Journals Online
subjects Animals
Carcinogenicity Tests - veterinary
Female
Incidence
Male
Neoplasms - epidemiology
Neoplasms - etiology
Neoplasms - veterinary
Organ Specificity
Rats
Rats, Sprague-Dawley
Rats, Wistar
Species Specificity
title Differences in Types and Incidence of Neoplasms in Wistar Han and Sprague-Dawley Rats
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T01%3A04%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Differences%20in%20Types%20and%20Incidence%20of%20Neoplasms%20in%20Wistar%20Han%20and%20Sprague-Dawley%20Rats&rft.jtitle=Toxicologic%20pathology&rft.au=Weber,%20Klaus&rft.date=2017-01&rft.volume=45&rft.issue=1&rft.spage=64&rft.epage=75&rft.pages=64-75&rft.issn=0192-6233&rft.eissn=1533-1601&rft_id=info:doi/10.1177/0192623316672075&rft_dat=%3Cproquest_cross%3E1868306086%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c478t-c4ada3df9641b2f121e7e113f74c0d284ef44bf09bb32385740ecc6895807d6d3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1857379585&rft_id=info:pmid/28068893&rft_sage_id=10.1177_0192623316672075&rfr_iscdi=true