One-stage revision of infected hip arthroplasty: outcome of 39 consecutive hips

• Published in: International orthopaedics 2016-05, Vol.40 (5), p.913-918
• Main Authors: Ilchmann, Thomas, Zimmerli, Werner, Ochsner, Peter Emil, Kessler, Bernhard, Zwicky, Lukas, Graber, Peter, Clauss, Martin
• Format: Article
• Language: English
• Subjects: Aged; Anti-Bacterial Agents - therapeutic use; Arthroplasty, Replacement, Hip - adverse effects; Arthroplasty, Replacement, Hip - methods; Cohort Studies; Debridement - methods; Female; Follow-Up Studies; Hip; Hip Joint - microbiology; Hip Joint - surgery; Hip Prosthesis - adverse effects; Humans; Male; Medicine; Medicine & Public Health; Middle Aged; Original Paper; Orthopedics; Prosthesis-Related Infections - microbiology; Prosthesis-Related Infections - therapy; Reoperation - methods; Treatment Outcome
• ISSN: 0341-2695; 1432-5195
• DOI: 10.1007/s00264-015-2833-4

Purpose There are various options for treating periprosthetic joint infection (PJI). Two-stage exchange has traditionally been the gold standard. However, if the appropriate surgical intervention is chosen according to a rational algorithm, the outcome is similar when using all types of interventions. In an observational cohort study, the outcome of patients with PJI after hip replacement treated with one-stage revision was analysed. Methods All patients fulfilling all criteria for one-stage exchange according to the Infectious Diseases Society of America (IDSA) guidelines and six without preoperative identification of a microorganism were included. Implant removal, debridement and cemented or uncemented reimplantations were performed in a single intervention. If a cemented device was implanted, commercially available gentamicin cement was used in all cases. Antibiotic treatment was administered intravenously for at least 2 weeks, followed by oral therapy for a total duration of 3 months. Patients had standardised clinical and radiological follow-up visits. Results Between 1996 and 2011, 38 patients (39 hips) were treated with a one-stage procedure and followed for at least 2 years. Coagulase-negative staphylococci were the most frequent pathogens, and polymicrobial infection was observed in five cases. In 25 hips, an uncemented revision stem was implanted, and 37 hips received an acetabular reinforcement ring. The mean follow-up was 6.6 (2.0–15.1) years. No patient had persistent, recurrent or new infection. There were four stem revisions for aseptic loosening. The mean Harris Hip Score was 81 points (26–99) at the final follow-up. Conclusions Excellent cure rate and function seen in our study suggest that one-stage exchange is a safe procedure, even without local antibiotic treatment, provided that the patient has no sinus tract or severe soft tissue damage, no major bone grafting is required and the microorganism is susceptible to orally administered agents with high bioavailability.