Delineating the Relationship Between Leptin, Fat Mass, and Bone Mineral Density: A Mediation Analysis

To test the hypothesis that the relationship between fat mass (FM) and bone mineral density (BMD) is mediated by leptin. The study involved 611 individuals aged 20–89 years who were randomly sampled from Ho Chi Minh City (Vietnam). BMD at the femoral neck (FN), lumbar spine (LS), and whole body (WB)...

Full description

Saved in:
Bibliographic Details
Published in:Calcified tissue international 2017-01, Vol.100 (1), p.13-19
Main Authors: Ho-Pham, Lan T., Lai, Thai Q., Nguyen, Uyen D. T., Bui, Quoc V., Nguyen, Tuan V.
Format: Article
Language:English
Subjects:
Adipose Tissue - metabolism
Adult
Aged
Aged, 80 and over
Aging - physiology
Biochemistry
Biomedical and Life Sciences
Body Composition - physiology
Body fat
Body Mass Index
Bone density
Bone Density - physiology
Cell Biology
Endocrinology
Female
Humans
Leptin - metabolism
Life Sciences
Male
Middle Aged
Original Research
Orthopedics
Osteoporosis, Postmenopausal - metabolism
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To test the hypothesis that the relationship between fat mass (FM) and bone mineral density (BMD) is mediated by leptin. The study involved 611 individuals aged 20–89 years who were randomly sampled from Ho Chi Minh City (Vietnam). BMD at the femoral neck (FN), lumbar spine (LS), and whole body (WB) was measured by DXA. Lean mass and FM were derived from the WB DXA scan. Leptin was measured by ELISA (DRG Diagnostics, Germany). The regression method was used to partition the variance of leptin and FM on BMD. The mediated effect of leptin was analyzed by the mediation analysis model. In the multiple linear regression, leptin, FM, and age collectively accounted for ~34 % variation in FNBMD in men and women. However, only 0.5 % of this explained variance was due to leptin. Of the total effect of FM on FNBMD, the mediated effect of leptin accounted for 6.1 % ( P  = 0.38) in men and 7.1 % ( P  = 0.99) in women. The same trend was observed for LS and WBBMD. These data suggest that greater FM is associated with greater BMD, but the association is not mediated by leptin, and that leptin has a non-significant influence on bone mass.
ISSN:0171-967X
1432-0827
DOI:10.1007/s00223-016-0196-5