High Vitamin D-Binding Protein Concentration, Low Albumin, and Mode of Remission Predict Relapse in Crohn's Disease

Vitamin D (25(OH)D) deficiency occurs in active Crohn's disease (CD) and may be secondary to reduced sunlight exposure and oral intake. Vitamin D-binding protein (VDBP) levels, however, fluctuate less with season and sunlight. The aim, therefore, was to examine patients with CD in remission and...

Full description

Saved in:
Bibliographic Details
Published in:Inflammatory bowel diseases 2016-10, Vol.22 (10), p.2456-2464
Main Authors: Ghaly, Simon, Murray, Kevin, Baird, Angela, Martin, Katherine, Prosser, Ruth, Mill, Justine, Simms, Lisa A, Hart, Prue H, Radford-Smith, Graham, Bampton, Peter A, Lawrance, Ian C
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Australia
Crohn Disease - blood
Crohn Disease - complications
Crohn Disease - therapy
Databases, Factual
Disease Progression
Humans
Middle Aged
Multivariate Analysis
Proportional Hazards Models
Prospective Studies
Recurrence
Remission Induction - methods
Retrospective Studies
Serum Albumin - analysis
Vitamin D - analogs & derivatives
Vitamin D - blood
Vitamin D Deficiency - etiology
Vitamin D-Binding Protein - blood
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Vitamin D (25(OH)D) deficiency occurs in active Crohn's disease (CD) and may be secondary to reduced sunlight exposure and oral intake. Vitamin D-binding protein (VDBP) levels, however, fluctuate less with season and sunlight. The aim, therefore, was to examine patients with CD in remission and determine any associations between VDBP, serum 25(OH)D, and the calculated free 25(OH)D concentrations with the risk of disease flare. Subjects were identified from prospectively maintained inflammatory bowel disease databases at 3 teaching hospitals in Australia. Patients were in steroid-free clinical remission at the time of blood draw and were followed for at least 12 months. Total and epimer-25(OH)D3, VDBP concentrations, and genotypes were determined. A total of 309 patients with CD (46% men) met the inclusion criteria. A disease flare occurred in 100 (32.4%). Serum 25(OH)D3 was deficient (
ISSN:1078-0998
1536-4844
DOI:10.1097/MIB.0000000000000894