Loading…
Impact of body mass index on the oncological outcomes of patients treated with radical cystectomy for muscle-invasive bladder cancer
Purpose Body mass index (BMI) has been associated with worse outcomes in several solid malignancies. We aimed to evaluate the association between BMI and oncological outcomes in patients treated with radical cystectomy (RC) for muscle-invasive urothelial carcinoma of the bladder (UCB). Methods We re...
Saved in:
| Published in: | World journal of urology 2017-02, Vol.35 (2), p.229-235 |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c405t-a38d672bc1eb49ab1b6d502676427dc17731f6c19b1c194e7fbfa7f652471ff13 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c405t-a38d672bc1eb49ab1b6d502676427dc17731f6c19b1c194e7fbfa7f652471ff13 |
| container_end_page | 235 |
| container_issue | 2 |
| container_start_page | 229 |
| container_title | World journal of urology |
| container_volume | 35 |
| creator | Dabi, Yohann Rouscoff, Yohann Anract, Julien Delongchamps, Nicolas Barry Sibony, Mathilde Saighi, Djillali Zerbib, Marc Peyraumore, Michael Xylinas, Evanguelos |
| description | Purpose
Body mass index (BMI) has been associated with worse outcomes in several solid malignancies. We aimed to evaluate the association between BMI and oncological outcomes in patients treated with radical cystectomy (RC) for muscle-invasive urothelial carcinoma of the bladder (UCB).
Methods
We retrospectively reviewed 701 consecutive patients treated with RC and pelvic lymphadenectomy for UCB at our institution between 1995 and 2011. Univariable and multivariable Cox regression models investigated the association of BMI with disease recurrence and cancer-specific mortality. BMI was analyzed as both continuous and categorical variable ( |
| doi_str_mv | 10.1007/s00345-016-1852-0 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1868312496</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4312389641</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-a38d672bc1eb49ab1b6d502676427dc17731f6c19b1c194e7fbfa7f652471ff13</originalsourceid><addsrcrecordid>eNqNkU1rFTEUhoMo9lr9AW4k4MZNNF-TzCylqC0U3Og65OOknTIzuSaZ2rv3h5vprSKCIAfOWeQ57yE8CL1k9C2jVL8rlArZEcoUYX3HCX2EdkwKQXrN1WO0o5pLIodenKBnpdxQyrSi3VN0wnUrTsUO_biY99ZXnCJ2KRzwbEvB4xLgDqcF12tow6cpXY3eTjit1acZyobvbR1hqQXXDLZCwN_Heo2zDfekP5QKvqb5gGPKeF6Ln4CMy60t4y1gN9kQIGNvFw_5OXoS7VTgxcM8RV8_fvhydk4uP3-6OHt_SbykXSVW9EFp7jwDJwfrmFOho1xpJbkOnmktWFSeDY61JkFHF62OquNSsxiZOEVvjrn7nL6tUKqZx-JhmuwCaS2G9aoXjMtB_QfKlRp0L3hDX_-F3qQ1L-0jW2DHO03FdpsdKZ9TKRmi2edxtvlgGDWbTXO0aZpNs9k0tO28ekhe3Qzh98YvfQ3gR6C0p-UK8h-n_5n6E8oTqxM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1865257031</pqid></control><display><type>article</type><title>Impact of body mass index on the oncological outcomes of patients treated with radical cystectomy for muscle-invasive bladder cancer</title><source>Springer Nature</source><creator>Dabi, Yohann ; Rouscoff, Yohann ; Anract, Julien ; Delongchamps, Nicolas Barry ; Sibony, Mathilde ; Saighi, Djillali ; Zerbib, Marc ; Peyraumore, Michael ; Xylinas, Evanguelos</creator><creatorcontrib>Dabi, Yohann ; Rouscoff, Yohann ; Anract, Julien ; Delongchamps, Nicolas Barry ; Sibony, Mathilde ; Saighi, Djillali ; Zerbib, Marc ; Peyraumore, Michael ; Xylinas, Evanguelos</creatorcontrib><description>Purpose
Body mass index (BMI) has been associated with worse outcomes in several solid malignancies. We aimed to evaluate the association between BMI and oncological outcomes in patients treated with radical cystectomy (RC) for muscle-invasive urothelial carcinoma of the bladder (UCB).
Methods
We retrospectively reviewed 701 consecutive patients treated with RC and pelvic lymphadenectomy for UCB at our institution between 1995 and 2011. Univariable and multivariable Cox regression models investigated the association of BMI with disease recurrence and cancer-specific mortality. BMI was analyzed as both continuous and categorical variable (<25 vs. 25–29 vs. ≥30 kg/m
2
).
Results
From the 701 patients, 275 (39.2 %) had a BMI < 25 kg/m
2
, 280 (39.9 %) had a BMI between 25 and 29.9 kg/m
2
, and 146 (20.9 %) had a BMI ⩾ 30 kg/m
2
. Within a median follow-up of 45 months (IQR 23–75), 163 patients (23.3 %) experienced a disease recurrence and 127 (18.1 %) died from the disease. In univariable analyses, BMI ⩾ 30 kg/m
2
was associated with a higher risk of disease recurrence and cancer-specific mortality (both
p
values <0.01). In multivariable analyses that adjusted for the effects of standard clinicopathological features, BMI ⩾ 30 kg/m
2
was associated with both higher risks of disease recurrence (HR 1.58; 95 % CI 1.06–2.34,
p
= 0.02) and cancer-specific mortality (HR 1.58; 95 % CI 1.01–2.48;
p
= 0.04).
Conclusions
Obesity was independently associated with higher risks of disease recurrence and cancer-specific mortality in patients treated with RC for muscle-invasive UCB. BMI is a modifiable feature that may have significant individual and public health implications in patients with muscle-invasive UCB.</description><identifier>ISSN: 0724-4983</identifier><identifier>EISSN: 1433-8726</identifier><identifier>DOI: 10.1007/s00345-016-1852-0</identifier><identifier>PMID: 27272203</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aged ; Bladder cancer ; Body Mass Index ; Carcinoma, Transitional Cell - mortality ; Carcinoma, Transitional Cell - pathology ; Carcinoma, Transitional Cell - surgery ; Cystectomy ; Female ; Humans ; Male ; Medicine ; Medicine & Public Health ; Muscle, Smooth ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local - epidemiology ; Nephrology ; Oncology ; Original Article ; Retrospective Studies ; Survival Rate ; Treatment Outcome ; Urinary Bladder Neoplasms - mortality ; Urinary Bladder Neoplasms - pathology ; Urinary Bladder Neoplasms - surgery ; Urology</subject><ispartof>World journal of urology, 2017-02, Vol.35 (2), p.229-235</ispartof><rights>Springer-Verlag Berlin Heidelberg 2016</rights><rights>World Journal of Urology is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-a38d672bc1eb49ab1b6d502676427dc17731f6c19b1c194e7fbfa7f652471ff13</citedby><cites>FETCH-LOGICAL-c405t-a38d672bc1eb49ab1b6d502676427dc17731f6c19b1c194e7fbfa7f652471ff13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27272203$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dabi, Yohann</creatorcontrib><creatorcontrib>Rouscoff, Yohann</creatorcontrib><creatorcontrib>Anract, Julien</creatorcontrib><creatorcontrib>Delongchamps, Nicolas Barry</creatorcontrib><creatorcontrib>Sibony, Mathilde</creatorcontrib><creatorcontrib>Saighi, Djillali</creatorcontrib><creatorcontrib>Zerbib, Marc</creatorcontrib><creatorcontrib>Peyraumore, Michael</creatorcontrib><creatorcontrib>Xylinas, Evanguelos</creatorcontrib><title>Impact of body mass index on the oncological outcomes of patients treated with radical cystectomy for muscle-invasive bladder cancer</title><title>World journal of urology</title><addtitle>World J Urol</addtitle><addtitle>World J Urol</addtitle><description>Purpose
Body mass index (BMI) has been associated with worse outcomes in several solid malignancies. We aimed to evaluate the association between BMI and oncological outcomes in patients treated with radical cystectomy (RC) for muscle-invasive urothelial carcinoma of the bladder (UCB).
Methods
We retrospectively reviewed 701 consecutive patients treated with RC and pelvic lymphadenectomy for UCB at our institution between 1995 and 2011. Univariable and multivariable Cox regression models investigated the association of BMI with disease recurrence and cancer-specific mortality. BMI was analyzed as both continuous and categorical variable (<25 vs. 25–29 vs. ≥30 kg/m
2
).
Results
From the 701 patients, 275 (39.2 %) had a BMI < 25 kg/m
2
, 280 (39.9 %) had a BMI between 25 and 29.9 kg/m
2
, and 146 (20.9 %) had a BMI ⩾ 30 kg/m
2
. Within a median follow-up of 45 months (IQR 23–75), 163 patients (23.3 %) experienced a disease recurrence and 127 (18.1 %) died from the disease. In univariable analyses, BMI ⩾ 30 kg/m
2
was associated with a higher risk of disease recurrence and cancer-specific mortality (both
p
values <0.01). In multivariable analyses that adjusted for the effects of standard clinicopathological features, BMI ⩾ 30 kg/m
2
was associated with both higher risks of disease recurrence (HR 1.58; 95 % CI 1.06–2.34,
p
= 0.02) and cancer-specific mortality (HR 1.58; 95 % CI 1.01–2.48;
p
= 0.04).
Conclusions
Obesity was independently associated with higher risks of disease recurrence and cancer-specific mortality in patients treated with RC for muscle-invasive UCB. BMI is a modifiable feature that may have significant individual and public health implications in patients with muscle-invasive UCB.</description><subject>Aged</subject><subject>Bladder cancer</subject><subject>Body Mass Index</subject><subject>Carcinoma, Transitional Cell - mortality</subject><subject>Carcinoma, Transitional Cell - pathology</subject><subject>Carcinoma, Transitional Cell - surgery</subject><subject>Cystectomy</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Muscle, Smooth</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Recurrence, Local - epidemiology</subject><subject>Nephrology</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Retrospective Studies</subject><subject>Survival Rate</subject><subject>Treatment Outcome</subject><subject>Urinary Bladder Neoplasms - mortality</subject><subject>Urinary Bladder Neoplasms - pathology</subject><subject>Urinary Bladder Neoplasms - surgery</subject><subject>Urology</subject><issn>0724-4983</issn><issn>1433-8726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqNkU1rFTEUhoMo9lr9AW4k4MZNNF-TzCylqC0U3Og65OOknTIzuSaZ2rv3h5vprSKCIAfOWeQ57yE8CL1k9C2jVL8rlArZEcoUYX3HCX2EdkwKQXrN1WO0o5pLIodenKBnpdxQyrSi3VN0wnUrTsUO_biY99ZXnCJ2KRzwbEvB4xLgDqcF12tow6cpXY3eTjit1acZyobvbR1hqQXXDLZCwN_Heo2zDfekP5QKvqb5gGPKeF6Ln4CMy60t4y1gN9kQIGNvFw_5OXoS7VTgxcM8RV8_fvhydk4uP3-6OHt_SbykXSVW9EFp7jwDJwfrmFOho1xpJbkOnmktWFSeDY61JkFHF62OquNSsxiZOEVvjrn7nL6tUKqZx-JhmuwCaS2G9aoXjMtB_QfKlRp0L3hDX_-F3qQ1L-0jW2DHO03FdpsdKZ9TKRmi2edxtvlgGDWbTXO0aZpNs9k0tO28ekhe3Qzh98YvfQ3gR6C0p-UK8h-n_5n6E8oTqxM</recordid><startdate>20170201</startdate><enddate>20170201</enddate><creator>Dabi, Yohann</creator><creator>Rouscoff, Yohann</creator><creator>Anract, Julien</creator><creator>Delongchamps, Nicolas Barry</creator><creator>Sibony, Mathilde</creator><creator>Saighi, Djillali</creator><creator>Zerbib, Marc</creator><creator>Peyraumore, Michael</creator><creator>Xylinas, Evanguelos</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20170201</creationdate><title>Impact of body mass index on the oncological outcomes of patients treated with radical cystectomy for muscle-invasive bladder cancer</title><author>Dabi, Yohann ; Rouscoff, Yohann ; Anract, Julien ; Delongchamps, Nicolas Barry ; Sibony, Mathilde ; Saighi, Djillali ; Zerbib, Marc ; Peyraumore, Michael ; Xylinas, Evanguelos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-a38d672bc1eb49ab1b6d502676427dc17731f6c19b1c194e7fbfa7f652471ff13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Bladder cancer</topic><topic>Body Mass Index</topic><topic>Carcinoma, Transitional Cell - mortality</topic><topic>Carcinoma, Transitional Cell - pathology</topic><topic>Carcinoma, Transitional Cell - surgery</topic><topic>Cystectomy</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Muscle, Smooth</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Recurrence, Local - epidemiology</topic><topic>Nephrology</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Retrospective Studies</topic><topic>Survival Rate</topic><topic>Treatment Outcome</topic><topic>Urinary Bladder Neoplasms - mortality</topic><topic>Urinary Bladder Neoplasms - pathology</topic><topic>Urinary Bladder Neoplasms - surgery</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dabi, Yohann</creatorcontrib><creatorcontrib>Rouscoff, Yohann</creatorcontrib><creatorcontrib>Anract, Julien</creatorcontrib><creatorcontrib>Delongchamps, Nicolas Barry</creatorcontrib><creatorcontrib>Sibony, Mathilde</creatorcontrib><creatorcontrib>Saighi, Djillali</creatorcontrib><creatorcontrib>Zerbib, Marc</creatorcontrib><creatorcontrib>Peyraumore, Michael</creatorcontrib><creatorcontrib>Xylinas, Evanguelos</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>World journal of urology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dabi, Yohann</au><au>Rouscoff, Yohann</au><au>Anract, Julien</au><au>Delongchamps, Nicolas Barry</au><au>Sibony, Mathilde</au><au>Saighi, Djillali</au><au>Zerbib, Marc</au><au>Peyraumore, Michael</au><au>Xylinas, Evanguelos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of body mass index on the oncological outcomes of patients treated with radical cystectomy for muscle-invasive bladder cancer</atitle><jtitle>World journal of urology</jtitle><stitle>World J Urol</stitle><addtitle>World J Urol</addtitle><date>2017-02-01</date><risdate>2017</risdate><volume>35</volume><issue>2</issue><spage>229</spage><epage>235</epage><pages>229-235</pages><issn>0724-4983</issn><eissn>1433-8726</eissn><abstract>Purpose
Body mass index (BMI) has been associated with worse outcomes in several solid malignancies. We aimed to evaluate the association between BMI and oncological outcomes in patients treated with radical cystectomy (RC) for muscle-invasive urothelial carcinoma of the bladder (UCB).
Methods
We retrospectively reviewed 701 consecutive patients treated with RC and pelvic lymphadenectomy for UCB at our institution between 1995 and 2011. Univariable and multivariable Cox regression models investigated the association of BMI with disease recurrence and cancer-specific mortality. BMI was analyzed as both continuous and categorical variable (<25 vs. 25–29 vs. ≥30 kg/m
2
).
Results
From the 701 patients, 275 (39.2 %) had a BMI < 25 kg/m
2
, 280 (39.9 %) had a BMI between 25 and 29.9 kg/m
2
, and 146 (20.9 %) had a BMI ⩾ 30 kg/m
2
. Within a median follow-up of 45 months (IQR 23–75), 163 patients (23.3 %) experienced a disease recurrence and 127 (18.1 %) died from the disease. In univariable analyses, BMI ⩾ 30 kg/m
2
was associated with a higher risk of disease recurrence and cancer-specific mortality (both
p
values <0.01). In multivariable analyses that adjusted for the effects of standard clinicopathological features, BMI ⩾ 30 kg/m
2
was associated with both higher risks of disease recurrence (HR 1.58; 95 % CI 1.06–2.34,
p
= 0.02) and cancer-specific mortality (HR 1.58; 95 % CI 1.01–2.48;
p
= 0.04).
Conclusions
Obesity was independently associated with higher risks of disease recurrence and cancer-specific mortality in patients treated with RC for muscle-invasive UCB. BMI is a modifiable feature that may have significant individual and public health implications in patients with muscle-invasive UCB.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>27272203</pmid><doi>10.1007/s00345-016-1852-0</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0724-4983 |
| ispartof | World journal of urology, 2017-02, Vol.35 (2), p.229-235 |
| issn | 0724-4983 1433-8726 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1868312496 |
| source | Springer Nature |
| subjects | Aged Bladder cancer Body Mass Index Carcinoma, Transitional Cell - mortality Carcinoma, Transitional Cell - pathology Carcinoma, Transitional Cell - surgery Cystectomy Female Humans Male Medicine Medicine & Public Health Muscle, Smooth Neoplasm Invasiveness Neoplasm Recurrence, Local - epidemiology Nephrology Oncology Original Article Retrospective Studies Survival Rate Treatment Outcome Urinary Bladder Neoplasms - mortality Urinary Bladder Neoplasms - pathology Urinary Bladder Neoplasms - surgery Urology |
| title | Impact of body mass index on the oncological outcomes of patients treated with radical cystectomy for muscle-invasive bladder cancer |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T02%3A50%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20body%20mass%20index%20on%20the%20oncological%20outcomes%20of%20patients%20treated%20with%20radical%20cystectomy%20for%20muscle-invasive%20bladder%20cancer&rft.jtitle=World%20journal%20of%20urology&rft.au=Dabi,%20Yohann&rft.date=2017-02-01&rft.volume=35&rft.issue=2&rft.spage=229&rft.epage=235&rft.pages=229-235&rft.issn=0724-4983&rft.eissn=1433-8726&rft_id=info:doi/10.1007/s00345-016-1852-0&rft_dat=%3Cproquest_cross%3E4312389641%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c405t-a38d672bc1eb49ab1b6d502676427dc17731f6c19b1c194e7fbfa7f652471ff13%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1865257031&rft_id=info:pmid/27272203&rfr_iscdi=true |