The emerging role of transcranial magnetic resonance imaging–guided focused ultrasound in functional neurosurgery

ABSTRACT To review the emerging role of transcranial MR‐guided focused ultrasound as a treatment and research modality for functional neurological disorders, we summarize recent clinical and preclinical studies. Clinical trials have investigated the safety and efficacy of thermal lesions created by...

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Bibliographic Details
Published in:Movement disorders 2017-01, Vol.32 (1), p.20-27
Main Authors: Weintraub, David, Elias, W. Jeffrey
Format: Article
Language:English
Subjects:
Animals
blood–brain barrier
Clinical trials
essential tremor
focused ultrasound
functional neurosurgery
High-Intensity Focused Ultrasound Ablation - methods
High-Intensity Focused Ultrasound Ablation - trends
Humans
Investigations
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Magnetic Resonance Imaging - trends
minimally invasive surgery
Movement disorders
Nervous System Diseases - surgery
Neuroimaging
Neurological diseases
Neuromodulation
Neurosurgery
Neurosurgical Procedures - methods
Neurosurgical Procedures - trends
obsessive‐compulsive disorder
Parkinson's disease
Surgery, Computer-Assisted - methods
Surgery, Computer-Assisted - trends
Ultrasonic imaging
Ultrasound
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Summary:ABSTRACT To review the emerging role of transcranial MR‐guided focused ultrasound as a treatment and research modality for functional neurological disorders, we summarize recent clinical and preclinical studies. Clinical trials have investigated the safety and efficacy of thermal lesions created by transcranial, high‐intensity focused ultrasound. Preclinical work has additionally investigated the ability to disrupt the blood–brain barrier and to produce reversible neuromodulation with focused ultrasound utilizing lower intensities. We discuss ongoing trials and future avenues of investigation. © 2016 International Parkinson and Movement Disorder Society
ISSN:0885-3185
1531-8257
DOI:10.1002/mds.26599