Corticosterone Induces Rapid Increase in the Amplitude of Inhibitory Response in Hippocampal Synapses with Asynchronous GABA Release

Experiments were performed on cultured slices of rat ventral hippocampus. Using extracellular stimulation and patch clamp recording from pyramidal neurons in the hippocampal CA1 area, we studied characteristics of GABAergic synapse formed on these neurons by cholecystokinin-expressing interneurons....

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2016-03, Vol.160 (5), p.628-631
Main Authors: Volkova, E. P., Rozov, A. V., Nadareishvili, G. G., Bol’shakov, A. P.
Format: Article
Language:English
Subjects:
Action Potentials - drug effects
Animals
Biomedical and Life Sciences
Biomedicine
Brain
Cell Biology
Cholecystokinin
Cholecystokinin - biosynthesis
Corticosterone
Corticosterone - pharmacology
Electric Stimulation
Evoked Potentials - drug effects
GABA
GABAergic Neurons - metabolism
gamma-Aminobutyric Acid - metabolism
gamma-Aminobutyric Acid - secretion
Hippocampus - drug effects
Hippocampus - physiology
Internal Medicine
Interneurons - metabolism
Laboratory Medicine
Neurons
Neurophysiology
Patch-Clamp Techniques
Pathology
Pyramidal Cells - physiology
Rats
Rats, Wistar
Steroids
Synapses - drug effects
Synaptic Transmission - drug effects
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Summary:Experiments were performed on cultured slices of rat ventral hippocampus. Using extracellular stimulation and patch clamp recording from pyramidal neurons in the hippocampal CA1 area, we studied characteristics of GABAergic synapse formed on these neurons by cholecystokinin-expressing interneurons. This synapse was characterized by asynchronous release of GABA and depolarization-induced suppression of inhibitory response. It was observed that administration of corticosterone increased the amplitude of evoked inhibitory postsynaptic currents in 5 minutes, but the paired ratio did not significantly change. Obtained data reflect that corticosterone can induce rapid genome-independent effects on inhibitory neurotransmission in one of hippocampal synapses.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-016-3234-4