Treatment of 100 chronic thalassemic leg wounds by plasma‐rich platelets

Objective Thalassemia is a heterogeneous group of congenital hemoglobinopathies caused by mutations in the globin gene complex that result in an unbalanced globin synthesis. Unmatched globin chains bind to the cytosolic surface of red blood cell membrane where they cause oxidative damage that might...

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Bibliographic Details
Published in:International journal of dermatology 2017-02, Vol.56 (2), p.171-175
Main Authors: Afradi, Hojjat, Saghaei, Yassaman, Kachoei, Zohre A., Babaei, Vahid, Teimourian, Shahram
Format: Article
Language:English
Subjects:
Adult
Blood
Chemokines
Cytokines
Deformability
Deformation mechanisms
Erythrocytes
Extrapolation
Female
Fibrin
Formability
Friability
Growth factors
Humans
Ischemia
Leg
Leg Ulcer - etiology
Leg Ulcer - therapy
Male
Mutation
Patients
Platelet-Rich Plasma
Platelets
Prospective Studies
Size reduction
Skin
Thalassemia
Thalassemia - complications
Time Factors
Treatment Outcome
Wound Healing
Wounds
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Summary:Objective Thalassemia is a heterogeneous group of congenital hemoglobinopathies caused by mutations in the globin gene complex that result in an unbalanced globin synthesis. Unmatched globin chains bind to the cytosolic surface of red blood cell membrane where they cause oxidative damage that might in part be responsible for membrane weakness. The deformability of red blood cells and hypercoagulable state in thalassemic patients have been incriminated in leg ulcer formation, as this might cause ischemia to the skin and consequently friability and ulceration. Methods Platelet‐rich plasma (PRP) gel is considered an advanced wound therapy for chronic and acute wounds. PRP gel consists of cytokines, growth factors, chemokines, and a fibrin scaffold derived from a patient's blood. In this study, we treated 100 thalassemic leg wounds using PRP. Results There was wound size reduction in patients after 4 weeks of treatment. In wounds with 2–3.5 cm2 surface area, complete closure happened after 12.5 weeks, 5–12 cm2 wounds completely closed after 13.2 weeks, and finally, 4.5–6 cm2 wounds healed completely after 14 weeks. None of the wounds reopened after 8 months of monitoring. Conclusion This study will help extrapolation of the use of PRP for at least thalassemic leg wound treatment.
ISSN:0011-9059
1365-4632
DOI:10.1111/ijd.13443