Impact of weight loss-associated changes in detailed body composition as assessed by whole-body MRI on plasma insulin levels and homeostatis model assessment index

Background/Objectives: We assessed the effect of weight loss-associated changes in detailed body composition on plasma insulin levels and homeostatic model assessment (HOMA) index to calculate the magnitude of reduction in different adipose tissue depots required to improve insulin sensitivity. Subj...

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Published in:European journal of clinical nutrition 2017-02, Vol.71 (2), p.212-218
Main Authors: Pourhassan, M, Glüer, C-C, Pick, P, Tigges, W, Müller, M J
Format: Article
Language:English
Subjects:
59/57
692/499
692/699/1702
Adipose tissue
Adipose Tissue - diagnostic imaging
Adipose Tissue - physiopathology
Adiposity - physiology
Adult
Aged
Bariatric Surgery
Body composition
Body Composition - physiology
Body fat
Body mass index
Body size
Body weight
Body weight loss
Caloric Restriction
Clinical Nutrition
Epidemiology
Female
Gastrointestinal surgery
Health aspects
Homeostasis
Homeostasis - physiology
Humans
Hypocaloric diet
Insulin
Insulin - blood
Insulin Resistance
Internal Medicine
Liver
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Methods
Middle Aged
Multiple regression analysis
Muscles
NMR
Nuclear magnetic resonance
Nutrient deficiency
Obesity - blood
Obesity - diagnostic imaging
Obesity - therapy
original-article
Plasma
Postoperative Period
Public Health
Skeletal muscle
Weight control
Weight loss
Weight Loss - physiology
Whole Body Imaging - methods
Young Adult
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container_title European journal of clinical nutrition
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description Background/Objectives: We assessed the effect of weight loss-associated changes in detailed body composition on plasma insulin levels and homeostatic model assessment (HOMA) index to calculate the magnitude of reduction in different adipose tissue depots required to improve insulin sensitivity. SubjectS/Methods: A total of 50 subjects aged 20–69 years were studied. The participants were compiled from low-calorie diet interventions and bariatric surgery and differed in their baseline body mass index (BMI; range 21.6–54.4 kg/m 2 ) and degree of weight losses (range −3.3 to −56.9 kg). Detailed body composition and liver fat were measured using whole-body magnetic resonance imaging (MRI). Insulin resistance was assessed by HOMA. Results: Mean body weight decreased by −16.0±13.6 kg. Significant changes were observed in total adipose tissue (TAT MRI , range −0.5 to −36.0 kg), total subcutaneous adipose tissue (SAT MRI ), visceral adipose tissue (VAT MRI ), skeletal muscle, liver fat, plasma insulin levels and HOMA. Decreases in insulin and HOMA were correlated with reductions in TAT MRI , SAT MRI , VAT MRI (just with HOMA) and liver fat. Losses of 2.9 and 6.5 kg body weight, 2.0 and 5.0 kg TAT MRI as well as 1.6 and 6% liver fat were required to decrease plasma insulin levels by 1 μU/ml and HOMA adjusted for baseline HOMA by 1 point. Multiple regression analysis showed that baseline liver fat and changes in liver fat explained 49.7% and 55.1% of the variance in weight loss-associated changes in plasma insulin and HOMA, respectively. Conclusions: Decreases of adipose tissues and liver fat are the major determinants of reduction in plasma insulin levels and improvement in HOMA index.
doi_str_mv 10.1038/ejcn.2016.189
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Glüer, C-C ; Pick, P ; Tigges, W ; Müller, M J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c732t-a2820ff6e5f2dd12cba20ba63ee0205a0545242b8247531cf630d242a5f22ba23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>59/57</topic><topic>692/499</topic><topic>692/699/1702</topic><topic>Adipose tissue</topic><topic>Adipose Tissue - diagnostic imaging</topic><topic>Adipose Tissue - physiopathology</topic><topic>Adiposity - physiology</topic><topic>Adult</topic><topic>Aged</topic><topic>Bariatric Surgery</topic><topic>Body composition</topic><topic>Body Composition - physiology</topic><topic>Body fat</topic><topic>Body mass index</topic><topic>Body size</topic><topic>Body weight</topic><topic>Body weight loss</topic><topic>Caloric Restriction</topic><topic>Clinical Nutrition</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Gastrointestinal surgery</topic><topic>Health aspects</topic><topic>Homeostasis</topic><topic>Homeostasis - physiology</topic><topic>Humans</topic><topic>Hypocaloric diet</topic><topic>Insulin</topic><topic>Insulin - blood</topic><topic>Insulin Resistance</topic><topic>Internal Medicine</topic><topic>Liver</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine &amp; 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identifier ISSN: 0954-3007
ispartof European journal of clinical nutrition, 2017-02, Vol.71 (2), p.212-218
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source Springer Nature; Free E-Journal (出版社公開部分のみ）
subjects 59/57
692/499
692/699/1702
Adipose tissue
Adipose Tissue - diagnostic imaging
Adipose Tissue - physiopathology
Adiposity - physiology
Adult
Aged
Bariatric Surgery
Body composition
Body Composition - physiology
Body fat
Body mass index
Body size
Body weight
Body weight loss
Caloric Restriction
Clinical Nutrition
Epidemiology
Female
Gastrointestinal surgery
Health aspects
Homeostasis
Homeostasis - physiology
Humans
Hypocaloric diet
Insulin
Insulin - blood
Insulin Resistance
Internal Medicine
Liver
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Methods
Middle Aged
Multiple regression analysis
Muscles
NMR
Nuclear magnetic resonance
Nutrient deficiency
Obesity - blood
Obesity - diagnostic imaging
Obesity - therapy
original-article
Plasma
Postoperative Period
Public Health
Skeletal muscle
Weight control
Weight loss
Weight Loss - physiology
Whole Body Imaging - methods
Young Adult
title Impact of weight loss-associated changes in detailed body composition as assessed by whole-body MRI on plasma insulin levels and homeostatis model assessment index
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