Interactions between lifestyle and MTHFR polymorphisms on homocysteine concentrations in young adults belonging to the 1982 Pelotas Birth Cohort

Background/Objectives: Homocysteine (Hcy) is a key intermediate in methionine metabolism. A high plasma concentration of Hcy is an independent risk factor for cardiovascular diseases among other determinants. In this study, we aimed to investigate the interactions between methylenetetrahydrofolate r...

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Published in:European journal of clinical nutrition 2017-02, Vol.71 (2), p.259-266
Main Authors: Oliveira, I O, Silva, L P, Borges, M C, Cruz, O M, Tessmann, J W, Motta, J V S, Seixas, F K, Horta, B L, Gigante, D P
Format: Article
Language:English
Subjects:
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Alcohols
Alleles
Amino acids
Blood
Brazil
Cardiovascular diseases
Chemiluminescence
Clinical Nutrition
Cohort Studies
Epidemiology
Female
Folic Acid - blood
Folic Acid Deficiency
Gene-Environment Interaction
Genetic aspects
Genetic polymorphisms
Genotype
Genotype & phenotype
Genotypes
Health aspects
Homocysteine
Homocysteine - blood
Humans
Immunoassays
Internal Medicine
Life Style
Lifestyles
Male
Males
Medicine
Medicine & Public Health
Metabolic Diseases
Metabolism
Methylenetetrahydrofolate Reductase (NADPH2) - genetics
original-article
Polymorphism
Polymorphism, Genetic
Public Health
Risk factors
Sex Factors
Smoking
Young Adult
Young adults
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Summary:Background/Objectives: Homocysteine (Hcy) is a key intermediate in methionine metabolism. A high plasma concentration of Hcy is an independent risk factor for cardiovascular diseases among other determinants. In this study, we aimed to investigate the interactions between methylenetetrahydrofolate reductase enzyme gene (MTHFR) polymorphisms and lifestyle variables (smoking, alcohol intake and physical activity) on Hcy concentrations in a young Brazilian population. Subjects/Methods: The study population comprised 3803 individuals from the Pelotas Birth Cohort, aged 22–23 years. Allelic discrimination assays and chemiluminescence immunoassays were performed for genotyping and serum Hcy measurements, respectively. Linear regression models were used to explore the effect of gene–lifestyle interactions on Hcy concentrations. Results: Men carrying the MTHFR 677TT genotype, who were also smokers and drinkers (⩾15 g of alcohol per day), had the highest concentration of Hcy ( P -value for the interaction
ISSN:0954-3007
1476-5640
DOI:10.1038/ejcn.2016.193