Effects of pericardiectomy on training- and myocardial infarction-induced left ventricular hypertrophy, chamber dimensions and gene expression

Abstract The primary purpose of the study was to evaluate whether a pericardiectomy (PERI) alters training- or myocardial infarction (MI)-induced left ventricular hypertrophy (LVH), chamber geometry, gene expression and/or running performance. Mice were randomized into 6 groups: naïve control (CONT)...

Full description

Saved in:
Bibliographic Details
Published in:International journal of sports medicine 2017-01, Vol.38 (1), p.27-34
Main Authors: Wolff, A. M., Rasmussen, T. P., Wichern, C. R., Peterson, M. R., Stayton, M. M., Thomas, D. P.
Format: Article
Language:English
Subjects:
Animals
Cytoskeletal Proteins - physiology
Echocardiography
Female
Gene Expression
Heart Ventricles - pathology
Hypertrophy, Left Ventricular - physiopathology
Male
Mice
Mice, Inbred C57BL
Muscle Proteins - physiology
Myocardial Infarction - physiopathology
Natriuretic Peptide, Brain - physiology
Pericardiectomy
Physical Conditioning, Animal
Physiology & Biochemistry
Random Allocation
Receptors, Adrenergic, beta - physiology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract The primary purpose of the study was to evaluate whether a pericardiectomy (PERI) alters training- or myocardial infarction (MI)-induced left ventricular hypertrophy (LVH), chamber geometry, gene expression and/or running performance. Mice were randomized into 6 groups: naïve control (CONT)-sedentary (Sed), CONT-trained (Tr), PERI-Sed, PERI-Tr, MI-Sed and MI-Tr. MI mice also received a pericardiectomy as part of the MI surgical procedure. 10 weeks of treadmill running resulted in enhanced running performance-to-exhaustion in all 3 trained groups (CONT-Tr, PERI-Tr, MI-Tr) compared to sedentary cohorts ( P
ISSN:0172-4622
1439-3964
DOI:10.1055/s-0042-115567