Molecular Markers Useful for Intraspecies Subtyping and Strain Differentiation of Dermatophytes

Dermatophytosis is a very common skin disorder and the most frequent infection encountered by practicing dermatologists. The identification, pathogenicity, biology, and epidemiology of dermatophytes, the causative agents of dermatophytosis, are of interest for both dermatologists and medical mycolog...

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Bibliographic Details
Published in:Mycopathologia (1975) 2017-02, Vol.182 (1-2), p.57-65
Main Authors: Mochizuki, Takashi, Takeda, Kiminobu, Anzawa, Kazushi
Format: Article
Language:English
Subjects:
Analysis
Arthrodermataceae - classification
Arthrodermataceae - genetics
Biomedical and Life Sciences
Dermatology
Drug resistance
Epidemiology
Eukaryotic Microbiology
Genetic Markers
Genomes
Health aspects
Infection
Infections
Life Sciences
Medical Microbiology
Microbial Ecology
Microbiology
Mitochondrial DNA
Molecular Epidemiology - methods
Molecular Typing - methods
Mycological Typing Techniques - methods
Phylogenetics
Plant Sciences
Ribosomal RNA
Skin
Skin diseases
Virulence (Microbiology)
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Summary:Dermatophytosis is a very common skin disorder and the most frequent infection encountered by practicing dermatologists. The identification, pathogenicity, biology, and epidemiology of dermatophytes, the causative agents of dermatophytosis, are of interest for both dermatologists and medical mycologists. Recent advances in molecular methods have provided new techniques for identifying dermatophytes, including intraspecies variations. Intraspecies subtyping and strain differentiation have made possible the tracking of infections, the identification of common sources of infections, recurrence or reinfection after treatment, and analysis of strain virulence and drug resistance. This review describes molecular methods of intraspecies subtyping and strain differentiation, including analyses of mitochondrial DNA and non-transcribed spacer regions of ribosomal RNA genes, random amplification of polymorphic DNA, and microsatellite markers, along with their advantages and limitations.
ISSN:0301-486X
1573-0832
DOI:10.1007/s11046-016-0041-4