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Differential effects of methylphenidate and atomoxetine on intrinsic brain activity in children with attention deficit hyperactivity disorder
Methylphenidate and atomoxetine are commonly prescribed for treating attention deficit hyperactivity disorder (ADHD). However, their therapeutic neural mechanisms remain unclear. After baseline evaluation including cognitive testing of the Cambridge Neuropsychological Test Automated Battery (CANTAB)...
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| Published in: | Psychological medicine 2016-11, Vol.46 (15), p.3173-3185 |
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| container_title | Psychological medicine |
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| creator | Shang, C. Y. Yan, C. G. Lin, H. Y. Tseng, W. Y. Castellanos, F. X. Gau, S. S. |
| description | Methylphenidate and atomoxetine are commonly prescribed for treating attention deficit hyperactivity disorder (ADHD). However, their therapeutic neural mechanisms remain unclear.
After baseline evaluation including cognitive testing of the Cambridge Neuropsychological Test Automated Battery (CANTAB), drug-naive children with ADHD (n = 46), aged 7-17 years, were randomly assigned to a 12-week treatment with methylphenidate (n = 22) or atomoxetine (n = 24). Intrinsic brain activity, including the fractional amplitude of low-frequency fluctuations (fALFF) and regional homogeneity (ReHo), was quantified via resting-state functional magnetic resonance imaging at baseline and week 12.
Reductions in inattentive symptoms were related to increased fALFF in the left superior temporal gyrus and left inferior parietal lobule for ADHD children treated with methylphenidate, and in the left lingual gyrus and left inferior occipital gyrus for ADHD children treated with atomoxetine. Hyperactivity/impulsivity symptom reductions were differentially related to increased fALFF in the methylphenidate group and to decreased fALFF in the atomoxetine group in bilateral precentral and postcentral gyri. Prediction analyses in the atomoxetine group revealed negative correlations between pre-treatment CANTAB simple reaction time and fALFF change in the left lingual gyrus and left inferior occipital gyrus, and positive correlations between pre-treatment CANTAB simple movement time and fALFF change in bilateral precentral and postcentral gyri and left precuneus, with a negative correlation between movement time and the fALFF change in the left lingual gyrus and the inferior occipital gyrus.
Our findings suggest differential neurophysiological mechanisms for the treatment effects of methylphenidate and atomoxetine in children with ADHD. |
| doi_str_mv | 10.1017/S0033291716001938 |
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After baseline evaluation including cognitive testing of the Cambridge Neuropsychological Test Automated Battery (CANTAB), drug-naive children with ADHD (n = 46), aged 7-17 years, were randomly assigned to a 12-week treatment with methylphenidate (n = 22) or atomoxetine (n = 24). Intrinsic brain activity, including the fractional amplitude of low-frequency fluctuations (fALFF) and regional homogeneity (ReHo), was quantified via resting-state functional magnetic resonance imaging at baseline and week 12.
Reductions in inattentive symptoms were related to increased fALFF in the left superior temporal gyrus and left inferior parietal lobule for ADHD children treated with methylphenidate, and in the left lingual gyrus and left inferior occipital gyrus for ADHD children treated with atomoxetine. Hyperactivity/impulsivity symptom reductions were differentially related to increased fALFF in the methylphenidate group and to decreased fALFF in the atomoxetine group in bilateral precentral and postcentral gyri. Prediction analyses in the atomoxetine group revealed negative correlations between pre-treatment CANTAB simple reaction time and fALFF change in the left lingual gyrus and left inferior occipital gyrus, and positive correlations between pre-treatment CANTAB simple movement time and fALFF change in bilateral precentral and postcentral gyri and left precuneus, with a negative correlation between movement time and the fALFF change in the left lingual gyrus and the inferior occipital gyrus.
Our findings suggest differential neurophysiological mechanisms for the treatment effects of methylphenidate and atomoxetine in children with ADHD.</description><identifier>ISSN: 0033-2917</identifier><identifier>EISSN: 1469-8978</identifier><identifier>DOI: 10.1017/S0033291716001938</identifier><identifier>PMID: 27574878</identifier><identifier>CODEN: PSMDCO</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adolescent ; Adrenergic Uptake Inhibitors - therapeutic use ; Atomoxetine ; Atomoxetine Hydrochloride - therapeutic use ; Attention Deficit Disorder with Hyperactivity - drug therapy ; Attention Deficit Disorder with Hyperactivity - physiopathology ; Attention deficit hyperactivity disorder ; Brain - diagnostic imaging ; Brain - physiopathology ; Brain activity ; Brain mapping ; Child ; Children ; Childrens health ; Cognitive ability ; Cortex (parietal) ; Dopamine Uptake Inhibitors - therapeutic use ; Female ; Fluctuations ; Frontal Lobe - diagnostic imaging ; Frontal Lobe - physiopathology ; Functional magnetic resonance imaging ; Functional Neuroimaging ; Humans ; Impulsive behavior ; Impulsivity ; Magnetic Resonance Imaging ; Male ; Mental health ; Methylphenidate ; Methylphenidate - therapeutic use ; Movement time ; Neuroimaging ; Neuropsychology ; NMR ; Nuclear magnetic resonance ; Occipital Lobe - diagnostic imaging ; Occipital Lobe - physiopathology ; Original Articles ; Parietal Lobe - diagnostic imaging ; Parietal Lobe - physiopathology ; Prescribed ; Reaction time task ; Regional variations ; Resting ; Somatosensory Cortex - diagnostic imaging ; Somatosensory Cortex - physiopathology ; Superior temporal gyrus ; Temporal gyrus ; Treatment Outcome</subject><ispartof>Psychological medicine, 2016-11, Vol.46 (15), p.3173-3185</ispartof><rights>Copyright © Cambridge University Press 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-a38f8561209fba4871785fdf0ab9f964260df9df156850708ab0ae297b6de24b3</citedby><cites>FETCH-LOGICAL-c406t-a38f8561209fba4871785fdf0ab9f964260df9df156850708ab0ae297b6de24b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1847410948/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1847410948?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,12845,21393,21394,27923,27924,30998,33610,33611,34529,34530,43732,44114,72731,73992,74410</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27574878$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shang, C. Y.</creatorcontrib><creatorcontrib>Yan, C. G.</creatorcontrib><creatorcontrib>Lin, H. Y.</creatorcontrib><creatorcontrib>Tseng, W. Y.</creatorcontrib><creatorcontrib>Castellanos, F. X.</creatorcontrib><creatorcontrib>Gau, S. S.</creatorcontrib><title>Differential effects of methylphenidate and atomoxetine on intrinsic brain activity in children with attention deficit hyperactivity disorder</title><title>Psychological medicine</title><addtitle>Psychol. Med</addtitle><description>Methylphenidate and atomoxetine are commonly prescribed for treating attention deficit hyperactivity disorder (ADHD). However, their therapeutic neural mechanisms remain unclear.
After baseline evaluation including cognitive testing of the Cambridge Neuropsychological Test Automated Battery (CANTAB), drug-naive children with ADHD (n = 46), aged 7-17 years, were randomly assigned to a 12-week treatment with methylphenidate (n = 22) or atomoxetine (n = 24). Intrinsic brain activity, including the fractional amplitude of low-frequency fluctuations (fALFF) and regional homogeneity (ReHo), was quantified via resting-state functional magnetic resonance imaging at baseline and week 12.
Reductions in inattentive symptoms were related to increased fALFF in the left superior temporal gyrus and left inferior parietal lobule for ADHD children treated with methylphenidate, and in the left lingual gyrus and left inferior occipital gyrus for ADHD children treated with atomoxetine. Hyperactivity/impulsivity symptom reductions were differentially related to increased fALFF in the methylphenidate group and to decreased fALFF in the atomoxetine group in bilateral precentral and postcentral gyri. Prediction analyses in the atomoxetine group revealed negative correlations between pre-treatment CANTAB simple reaction time and fALFF change in the left lingual gyrus and left inferior occipital gyrus, and positive correlations between pre-treatment CANTAB simple movement time and fALFF change in bilateral precentral and postcentral gyri and left precuneus, with a negative correlation between movement time and the fALFF change in the left lingual gyrus and the inferior occipital gyrus.
Our findings suggest differential neurophysiological mechanisms for the treatment effects of methylphenidate and atomoxetine in children with ADHD.</description><subject>Adolescent</subject><subject>Adrenergic Uptake Inhibitors - therapeutic use</subject><subject>Atomoxetine</subject><subject>Atomoxetine Hydrochloride - therapeutic use</subject><subject>Attention Deficit Disorder with Hyperactivity - drug therapy</subject><subject>Attention Deficit Disorder with Hyperactivity - physiopathology</subject><subject>Attention deficit hyperactivity disorder</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - physiopathology</subject><subject>Brain activity</subject><subject>Brain mapping</subject><subject>Child</subject><subject>Children</subject><subject>Childrens health</subject><subject>Cognitive ability</subject><subject>Cortex (parietal)</subject><subject>Dopamine Uptake Inhibitors - therapeutic use</subject><subject>Female</subject><subject>Fluctuations</subject><subject>Frontal Lobe - diagnostic imaging</subject><subject>Frontal Lobe - physiopathology</subject><subject>Functional magnetic resonance imaging</subject><subject>Functional Neuroimaging</subject><subject>Humans</subject><subject>Impulsive behavior</subject><subject>Impulsivity</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Mental health</subject><subject>Methylphenidate</subject><subject>Methylphenidate - therapeutic use</subject><subject>Movement time</subject><subject>Neuroimaging</subject><subject>Neuropsychology</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Occipital Lobe - diagnostic imaging</subject><subject>Occipital Lobe - physiopathology</subject><subject>Original Articles</subject><subject>Parietal Lobe - diagnostic imaging</subject><subject>Parietal Lobe - physiopathology</subject><subject>Prescribed</subject><subject>Reaction time task</subject><subject>Regional variations</subject><subject>Resting</subject><subject>Somatosensory Cortex - diagnostic imaging</subject><subject>Somatosensory Cortex - physiopathology</subject><subject>Superior temporal gyrus</subject><subject>Temporal gyrus</subject><subject>Treatment Outcome</subject><issn>0033-2917</issn><issn>1469-8978</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>7QJ</sourceid><sourceid>ALSLI</sourceid><sourceid>HEHIP</sourceid><sourceid>M2S</sourceid><recordid>eNqNkc2KFTEUhIMoznX0AdxIwI2b1qSTzs9Sxl8YcKGum3TnxD5Dd_qa5I7eh_CdTTPXQRTBVQL1VRWHIuQxZ8854_rFR8aEaC3XXDHGrTB3yI5LZRtjtblLdpvcbPoZeZDzVWUEl-19ctbqTkujzY78eIUhQIJY0M0U6n8sma6BLlCm47yfIKJ3BaiLnrqyLut3KBiBrpFiLAljxpEOyWGkbix4jeVYBTpOOPsaS79hmaqxbA3V4yHgiIVOxz2kW4PHvCYP6SG5F9yc4dHpPSef37z-dPGuufzw9v3Fy8tmlEyVxgkTTKd4y2wYXD2Ea9MFH5gbbLBKtor5YH3gnTId08y4gTlorR6Uh1YO4pw8u8ndp_XrAXLpF8wjzLOLsB5yz40yolYp_h-o6DrBhTAVffoHerUeUqyHVEpqyZmVG8VvqDGtOScI_T7h4tKx56zfZu3_mrV6npySD8MC_tbxa8cKiFOoW4aE_gv81v3P2J-M7K7F</recordid><startdate>201611</startdate><enddate>201611</enddate><creator>Shang, C. 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Y.</au><au>Yan, C. G.</au><au>Lin, H. Y.</au><au>Tseng, W. Y.</au><au>Castellanos, F. X.</au><au>Gau, S. S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential effects of methylphenidate and atomoxetine on intrinsic brain activity in children with attention deficit hyperactivity disorder</atitle><jtitle>Psychological medicine</jtitle><addtitle>Psychol. Med</addtitle><date>2016-11</date><risdate>2016</risdate><volume>46</volume><issue>15</issue><spage>3173</spage><epage>3185</epage><pages>3173-3185</pages><issn>0033-2917</issn><eissn>1469-8978</eissn><coden>PSMDCO</coden><abstract>Methylphenidate and atomoxetine are commonly prescribed for treating attention deficit hyperactivity disorder (ADHD). However, their therapeutic neural mechanisms remain unclear.
After baseline evaluation including cognitive testing of the Cambridge Neuropsychological Test Automated Battery (CANTAB), drug-naive children with ADHD (n = 46), aged 7-17 years, were randomly assigned to a 12-week treatment with methylphenidate (n = 22) or atomoxetine (n = 24). Intrinsic brain activity, including the fractional amplitude of low-frequency fluctuations (fALFF) and regional homogeneity (ReHo), was quantified via resting-state functional magnetic resonance imaging at baseline and week 12.
Reductions in inattentive symptoms were related to increased fALFF in the left superior temporal gyrus and left inferior parietal lobule for ADHD children treated with methylphenidate, and in the left lingual gyrus and left inferior occipital gyrus for ADHD children treated with atomoxetine. Hyperactivity/impulsivity symptom reductions were differentially related to increased fALFF in the methylphenidate group and to decreased fALFF in the atomoxetine group in bilateral precentral and postcentral gyri. Prediction analyses in the atomoxetine group revealed negative correlations between pre-treatment CANTAB simple reaction time and fALFF change in the left lingual gyrus and left inferior occipital gyrus, and positive correlations between pre-treatment CANTAB simple movement time and fALFF change in bilateral precentral and postcentral gyri and left precuneus, with a negative correlation between movement time and the fALFF change in the left lingual gyrus and the inferior occipital gyrus.
Our findings suggest differential neurophysiological mechanisms for the treatment effects of methylphenidate and atomoxetine in children with ADHD.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>27574878</pmid><doi>10.1017/S0033291716001938</doi><tpages>13</tpages></addata></record> |
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| ispartof | Psychological medicine, 2016-11, Vol.46 (15), p.3173-3185 |
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| source | Applied Social Sciences Index & Abstracts (ASSIA); Cambridge Journals Online; Social Science Premium Collection; Sociology Collection |
| subjects | Adolescent Adrenergic Uptake Inhibitors - therapeutic use Atomoxetine Atomoxetine Hydrochloride - therapeutic use Attention Deficit Disorder with Hyperactivity - drug therapy Attention Deficit Disorder with Hyperactivity - physiopathology Attention deficit hyperactivity disorder Brain - diagnostic imaging Brain - physiopathology Brain activity Brain mapping Child Children Childrens health Cognitive ability Cortex (parietal) Dopamine Uptake Inhibitors - therapeutic use Female Fluctuations Frontal Lobe - diagnostic imaging Frontal Lobe - physiopathology Functional magnetic resonance imaging Functional Neuroimaging Humans Impulsive behavior Impulsivity Magnetic Resonance Imaging Male Mental health Methylphenidate Methylphenidate - therapeutic use Movement time Neuroimaging Neuropsychology NMR Nuclear magnetic resonance Occipital Lobe - diagnostic imaging Occipital Lobe - physiopathology Original Articles Parietal Lobe - diagnostic imaging Parietal Lobe - physiopathology Prescribed Reaction time task Regional variations Resting Somatosensory Cortex - diagnostic imaging Somatosensory Cortex - physiopathology Superior temporal gyrus Temporal gyrus Treatment Outcome |
| title | Differential effects of methylphenidate and atomoxetine on intrinsic brain activity in children with attention deficit hyperactivity disorder |
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