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Distinguishing ischaemic optic neuropathy from optic neuritis by ganglion cell analysis
Purpose To determine whether a pattern of altitudinal ganglion cell loss, as detected and measured by optical coherence tomography (OCT), can be used to distinguish non‐arteritic ischaemic optic neuropathy (NAION) from optic neuritis (ON) during the acute phase, and whether the rate or severity of g...
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Published in: | Acta ophthalmologica (Oxford, England) England), 2016-12, Vol.94 (8), p.e721-e726 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Purpose
To determine whether a pattern of altitudinal ganglion cell loss, as detected and measured by optical coherence tomography (OCT), can be used to distinguish non‐arteritic ischaemic optic neuropathy (NAION) from optic neuritis (ON) during the acute phase, and whether the rate or severity of ganglion cell loss differs between the two diseases.
Methods
We performed a retrospective, case–control study of 44 patients (50 eyes) with ON or NAION and 44 age‐matched controls. Non‐arteritic ischaemic optic neuropathy and ON patients had OCT at presentation and four consecutive follow‐up visits. Controls had OCT at one point in time. The ganglion cell complex (GCC) was evaluated in the macula, and the retinal nerve fibre layer (RNFL) was evaluated in the peripapillary region. Ganglion cell complex thickness, RNFL thickness and GCC mean superior and inferior hemispheric difference were compared between NAION and ON patients at each time‐point using unpaired t‐tests and between disease and control subjects at first measurement using paired t‐tests.
Results
Mean time from onset of symptoms to initial presentation was 10.7 ± 6.6 days in NAION and 11.7 ± 8.6 days in ON (p = 0.67). There was a significantly greater vertical hemispheric difference in GCC thickness in NAION patients than ON patients at all time‐points (5.5–10.7 μm versus 3.1–3.6 μm, p = 0.01–0.049). Mean GCC thickness was significantly decreased at less than 2 weeks after onset in NAION compared to age‐matched controls (72.1 μm versus 82.1 μm, p |
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ISSN: | 1755-375X 1755-3768 |
DOI: | 10.1111/aos.13128 |