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Distinguishing ischaemic optic neuropathy from optic neuritis by ganglion cell analysis
Purpose To determine whether a pattern of altitudinal ganglion cell loss, as detected and measured by optical coherence tomography (OCT), can be used to distinguish non‐arteritic ischaemic optic neuropathy (NAION) from optic neuritis (ON) during the acute phase, and whether the rate or severity of g...
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| Published in: | Acta ophthalmologica (Oxford, England) England), 2016-12, Vol.94 (8), p.e721-e726 |
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| container_title | Acta ophthalmologica (Oxford, England) |
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| creator | Erlich‐Malona, Natalie Mendoza‐Santiesteban, Carlos E. Hedges, Thomas R. Patel, Nimesh Monaco, Caitlin Cole, Emily |
| description | Purpose
To determine whether a pattern of altitudinal ganglion cell loss, as detected and measured by optical coherence tomography (OCT), can be used to distinguish non‐arteritic ischaemic optic neuropathy (NAION) from optic neuritis (ON) during the acute phase, and whether the rate or severity of ganglion cell loss differs between the two diseases.
Methods
We performed a retrospective, case–control study of 44 patients (50 eyes) with ON or NAION and 44 age‐matched controls. Non‐arteritic ischaemic optic neuropathy and ON patients had OCT at presentation and four consecutive follow‐up visits. Controls had OCT at one point in time. The ganglion cell complex (GCC) was evaluated in the macula, and the retinal nerve fibre layer (RNFL) was evaluated in the peripapillary region. Ganglion cell complex thickness, RNFL thickness and GCC mean superior and inferior hemispheric difference were compared between NAION and ON patients at each time‐point using unpaired t‐tests and between disease and control subjects at first measurement using paired t‐tests.
Results
Mean time from onset of symptoms to initial presentation was 10.7 ± 6.6 days in NAION and 11.7 ± 8.6 days in ON (p = 0.67). There was a significantly greater vertical hemispheric difference in GCC thickness in NAION patients than ON patients at all time‐points (5.5–10.7 μm versus 3.1–3.6 μm, p = 0.01–0.049). Mean GCC thickness was significantly decreased at less than 2 weeks after onset in NAION compared to age‐matched controls (72.1 μm versus 82.1 μm, p |
| doi_str_mv | 10.1111/aos.13128 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1868341720</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1904770107</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4498-24a14895a0b866bdb8666e3ac4af9798a0bd485171cfa06818c2d7c2d024d54a3</originalsourceid><addsrcrecordid>eNqNkV1LwzAUhoMobk4v_ANS8EYvuiVpmqSXY36CsAsVvQtpmm4ZbTObFum_N7NziKB44HxweHg5hxeAUwTHyMdEWjdGEcJ8DwwRi-MwYpTv7-b4dQCOnFtBSBGl5BAMMIsoiVEyBC9XxjWmWrTGLX0LjFNLqUujArtufK10W9u1bJZdkNe2_LY1jXFB2gULWS0KY6tA6aIIZCWLzhl3DA5yWTh9su0j8Hxz_TS7Cx_mt_ez6UOoCEl4iIlEhCexhCmnNM02lepIKiLzhCXc7zPCY8SQyiWkHHGFM-YTYpLFREYjcNHrrmv71mrXiNK_4C-RlbatE4hTHhHEMPwHiimDCcfYo-c_0JVta_-apxJIGIMIsj8pTggjlGDqqcueUrV1rta5WNemlHUnEBQb-4S3T3za59mzrWKbljrbkV9-eWDSA--m0N3vSmI6f-wlPwCz9aKt</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1844746426</pqid></control><display><type>article</type><title>Distinguishing ischaemic optic neuropathy from optic neuritis by ganglion cell analysis</title><source>Wiley</source><creator>Erlich‐Malona, Natalie ; Mendoza‐Santiesteban, Carlos E. ; Hedges, Thomas R. ; Patel, Nimesh ; Monaco, Caitlin ; Cole, Emily</creator><creatorcontrib>Erlich‐Malona, Natalie ; Mendoza‐Santiesteban, Carlos E. ; Hedges, Thomas R. ; Patel, Nimesh ; Monaco, Caitlin ; Cole, Emily</creatorcontrib><description>Purpose
To determine whether a pattern of altitudinal ganglion cell loss, as detected and measured by optical coherence tomography (OCT), can be used to distinguish non‐arteritic ischaemic optic neuropathy (NAION) from optic neuritis (ON) during the acute phase, and whether the rate or severity of ganglion cell loss differs between the two diseases.
Methods
We performed a retrospective, case–control study of 44 patients (50 eyes) with ON or NAION and 44 age‐matched controls. Non‐arteritic ischaemic optic neuropathy and ON patients had OCT at presentation and four consecutive follow‐up visits. Controls had OCT at one point in time. The ganglion cell complex (GCC) was evaluated in the macula, and the retinal nerve fibre layer (RNFL) was evaluated in the peripapillary region. Ganglion cell complex thickness, RNFL thickness and GCC mean superior and inferior hemispheric difference were compared between NAION and ON patients at each time‐point using unpaired t‐tests and between disease and control subjects at first measurement using paired t‐tests.
Results
Mean time from onset of symptoms to initial presentation was 10.7 ± 6.6 days in NAION and 11.7 ± 8.6 days in ON (p = 0.67). There was a significantly greater vertical hemispheric difference in GCC thickness in NAION patients than ON patients at all time‐points (5.5–10.7 μm versus 3.1–3.6 μm, p = 0.01–0.049). Mean GCC thickness was significantly decreased at less than 2 weeks after onset in NAION compared to age‐matched controls (72.1 μm versus 82.1 μm, p < 0.001), as well as in ON compared to age‐matched controls (74.3 μm versus 84.5 μm, p < 0.001). Progression and severity of GCC and RNFL loss did not differ significantly between NAION and ON.
Conclusion
A quantitative comparison of mean superior and inferior hemispheric GCC thickness with OCT may be used to distinguish NAION from ON.</description><identifier>ISSN: 1755-375X</identifier><identifier>EISSN: 1755-3768</identifier><identifier>DOI: 10.1111/aos.13128</identifier><identifier>PMID: 27364519</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adult ; Aged ; Case-Control Studies ; Diseases ; Female ; ganglion cell complex ; Humans ; ischaemic optic neuropathy ; Male ; Middle Aged ; Nerve Fibers - pathology ; Neuritis ; OCT ; Ophthalmology ; Optic neuritis ; Optic Neuritis - diagnosis ; Optic neuropathy ; Optic Neuropathy, Ischemic - diagnosis ; Optical Coherence Tomography ; Retina ; Retinal Ganglion Cells - pathology ; retinal nerve fibre layer ; Retrospective Studies ; Time measurement ; Tomography ; Tomography, Optical Coherence</subject><ispartof>Acta ophthalmologica (Oxford, England), 2016-12, Vol.94 (8), p.e721-e726</ispartof><rights>2016 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd</rights><rights>2016 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2016 Acta Ophthalmologica Scandinavica Foundation</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4498-24a14895a0b866bdb8666e3ac4af9798a0bd485171cfa06818c2d7c2d024d54a3</citedby><cites>FETCH-LOGICAL-c4498-24a14895a0b866bdb8666e3ac4af9798a0bd485171cfa06818c2d7c2d024d54a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27364519$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Erlich‐Malona, Natalie</creatorcontrib><creatorcontrib>Mendoza‐Santiesteban, Carlos E.</creatorcontrib><creatorcontrib>Hedges, Thomas R.</creatorcontrib><creatorcontrib>Patel, Nimesh</creatorcontrib><creatorcontrib>Monaco, Caitlin</creatorcontrib><creatorcontrib>Cole, Emily</creatorcontrib><title>Distinguishing ischaemic optic neuropathy from optic neuritis by ganglion cell analysis</title><title>Acta ophthalmologica (Oxford, England)</title><addtitle>Acta Ophthalmol</addtitle><description>Purpose
To determine whether a pattern of altitudinal ganglion cell loss, as detected and measured by optical coherence tomography (OCT), can be used to distinguish non‐arteritic ischaemic optic neuropathy (NAION) from optic neuritis (ON) during the acute phase, and whether the rate or severity of ganglion cell loss differs between the two diseases.
Methods
We performed a retrospective, case–control study of 44 patients (50 eyes) with ON or NAION and 44 age‐matched controls. Non‐arteritic ischaemic optic neuropathy and ON patients had OCT at presentation and four consecutive follow‐up visits. Controls had OCT at one point in time. The ganglion cell complex (GCC) was evaluated in the macula, and the retinal nerve fibre layer (RNFL) was evaluated in the peripapillary region. Ganglion cell complex thickness, RNFL thickness and GCC mean superior and inferior hemispheric difference were compared between NAION and ON patients at each time‐point using unpaired t‐tests and between disease and control subjects at first measurement using paired t‐tests.
Results
Mean time from onset of symptoms to initial presentation was 10.7 ± 6.6 days in NAION and 11.7 ± 8.6 days in ON (p = 0.67). There was a significantly greater vertical hemispheric difference in GCC thickness in NAION patients than ON patients at all time‐points (5.5–10.7 μm versus 3.1–3.6 μm, p = 0.01–0.049). Mean GCC thickness was significantly decreased at less than 2 weeks after onset in NAION compared to age‐matched controls (72.1 μm versus 82.1 μm, p < 0.001), as well as in ON compared to age‐matched controls (74.3 μm versus 84.5 μm, p < 0.001). Progression and severity of GCC and RNFL loss did not differ significantly between NAION and ON.
Conclusion
A quantitative comparison of mean superior and inferior hemispheric GCC thickness with OCT may be used to distinguish NAION from ON.</description><subject>Adult</subject><subject>Aged</subject><subject>Case-Control Studies</subject><subject>Diseases</subject><subject>Female</subject><subject>ganglion cell complex</subject><subject>Humans</subject><subject>ischaemic optic neuropathy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nerve Fibers - pathology</subject><subject>Neuritis</subject><subject>OCT</subject><subject>Ophthalmology</subject><subject>Optic neuritis</subject><subject>Optic Neuritis - diagnosis</subject><subject>Optic neuropathy</subject><subject>Optic Neuropathy, Ischemic - diagnosis</subject><subject>Optical Coherence Tomography</subject><subject>Retina</subject><subject>Retinal Ganglion Cells - pathology</subject><subject>retinal nerve fibre layer</subject><subject>Retrospective Studies</subject><subject>Time measurement</subject><subject>Tomography</subject><subject>Tomography, Optical Coherence</subject><issn>1755-375X</issn><issn>1755-3768</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqNkV1LwzAUhoMobk4v_ANS8EYvuiVpmqSXY36CsAsVvQtpmm4ZbTObFum_N7NziKB44HxweHg5hxeAUwTHyMdEWjdGEcJ8DwwRi-MwYpTv7-b4dQCOnFtBSBGl5BAMMIsoiVEyBC9XxjWmWrTGLX0LjFNLqUujArtufK10W9u1bJZdkNe2_LY1jXFB2gULWS0KY6tA6aIIZCWLzhl3DA5yWTh9su0j8Hxz_TS7Cx_mt_ez6UOoCEl4iIlEhCexhCmnNM02lepIKiLzhCXc7zPCY8SQyiWkHHGFM-YTYpLFREYjcNHrrmv71mrXiNK_4C-RlbatE4hTHhHEMPwHiimDCcfYo-c_0JVta_-apxJIGIMIsj8pTggjlGDqqcueUrV1rta5WNemlHUnEBQb-4S3T3za59mzrWKbljrbkV9-eWDSA--m0N3vSmI6f-wlPwCz9aKt</recordid><startdate>201612</startdate><enddate>201612</enddate><creator>Erlich‐Malona, Natalie</creator><creator>Mendoza‐Santiesteban, Carlos E.</creator><creator>Hedges, Thomas R.</creator><creator>Patel, Nimesh</creator><creator>Monaco, Caitlin</creator><creator>Cole, Emily</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>201612</creationdate><title>Distinguishing ischaemic optic neuropathy from optic neuritis by ganglion cell analysis</title><author>Erlich‐Malona, Natalie ; Mendoza‐Santiesteban, Carlos E. ; Hedges, Thomas R. ; Patel, Nimesh ; Monaco, Caitlin ; Cole, Emily</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4498-24a14895a0b866bdb8666e3ac4af9798a0bd485171cfa06818c2d7c2d024d54a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Case-Control Studies</topic><topic>Diseases</topic><topic>Female</topic><topic>ganglion cell complex</topic><topic>Humans</topic><topic>ischaemic optic neuropathy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nerve Fibers - pathology</topic><topic>Neuritis</topic><topic>OCT</topic><topic>Ophthalmology</topic><topic>Optic neuritis</topic><topic>Optic Neuritis - diagnosis</topic><topic>Optic neuropathy</topic><topic>Optic Neuropathy, Ischemic - diagnosis</topic><topic>Optical Coherence Tomography</topic><topic>Retina</topic><topic>Retinal Ganglion Cells - pathology</topic><topic>retinal nerve fibre layer</topic><topic>Retrospective Studies</topic><topic>Time measurement</topic><topic>Tomography</topic><topic>Tomography, Optical Coherence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Erlich‐Malona, Natalie</creatorcontrib><creatorcontrib>Mendoza‐Santiesteban, Carlos E.</creatorcontrib><creatorcontrib>Hedges, Thomas R.</creatorcontrib><creatorcontrib>Patel, Nimesh</creatorcontrib><creatorcontrib>Monaco, Caitlin</creatorcontrib><creatorcontrib>Cole, Emily</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Acta ophthalmologica (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Erlich‐Malona, Natalie</au><au>Mendoza‐Santiesteban, Carlos E.</au><au>Hedges, Thomas R.</au><au>Patel, Nimesh</au><au>Monaco, Caitlin</au><au>Cole, Emily</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distinguishing ischaemic optic neuropathy from optic neuritis by ganglion cell analysis</atitle><jtitle>Acta ophthalmologica (Oxford, England)</jtitle><addtitle>Acta Ophthalmol</addtitle><date>2016-12</date><risdate>2016</risdate><volume>94</volume><issue>8</issue><spage>e721</spage><epage>e726</epage><pages>e721-e726</pages><issn>1755-375X</issn><eissn>1755-3768</eissn><abstract>Purpose
To determine whether a pattern of altitudinal ganglion cell loss, as detected and measured by optical coherence tomography (OCT), can be used to distinguish non‐arteritic ischaemic optic neuropathy (NAION) from optic neuritis (ON) during the acute phase, and whether the rate or severity of ganglion cell loss differs between the two diseases.
Methods
We performed a retrospective, case–control study of 44 patients (50 eyes) with ON or NAION and 44 age‐matched controls. Non‐arteritic ischaemic optic neuropathy and ON patients had OCT at presentation and four consecutive follow‐up visits. Controls had OCT at one point in time. The ganglion cell complex (GCC) was evaluated in the macula, and the retinal nerve fibre layer (RNFL) was evaluated in the peripapillary region. Ganglion cell complex thickness, RNFL thickness and GCC mean superior and inferior hemispheric difference were compared between NAION and ON patients at each time‐point using unpaired t‐tests and between disease and control subjects at first measurement using paired t‐tests.
Results
Mean time from onset of symptoms to initial presentation was 10.7 ± 6.6 days in NAION and 11.7 ± 8.6 days in ON (p = 0.67). There was a significantly greater vertical hemispheric difference in GCC thickness in NAION patients than ON patients at all time‐points (5.5–10.7 μm versus 3.1–3.6 μm, p = 0.01–0.049). Mean GCC thickness was significantly decreased at less than 2 weeks after onset in NAION compared to age‐matched controls (72.1 μm versus 82.1 μm, p < 0.001), as well as in ON compared to age‐matched controls (74.3 μm versus 84.5 μm, p < 0.001). Progression and severity of GCC and RNFL loss did not differ significantly between NAION and ON.
Conclusion
A quantitative comparison of mean superior and inferior hemispheric GCC thickness with OCT may be used to distinguish NAION from ON.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>27364519</pmid><doi>10.1111/aos.13128</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Acta ophthalmologica (Oxford, England), 2016-12, Vol.94 (8), p.e721-e726 |
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| subjects | Adult Aged Case-Control Studies Diseases Female ganglion cell complex Humans ischaemic optic neuropathy Male Middle Aged Nerve Fibers - pathology Neuritis OCT Ophthalmology Optic neuritis Optic Neuritis - diagnosis Optic neuropathy Optic Neuropathy, Ischemic - diagnosis Optical Coherence Tomography Retina Retinal Ganglion Cells - pathology retinal nerve fibre layer Retrospective Studies Time measurement Tomography Tomography, Optical Coherence |
| title | Distinguishing ischaemic optic neuropathy from optic neuritis by ganglion cell analysis |
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