Genomic analysis of the evolutionary lineage of Norovirus GII.4 from archival specimens during 1975–1987 in Tokyo

This study aimed to analyze NoV GII.4 sequences from archival specimens obtained during 1975–1987 by comparing them with reference sequences. The first NoV GII.P4_GII.4 sequence was identified in 1980. NoV GII.4 collected in 1970 had a GII.P1_GII.4 sequence. These results indicate that the GII.P4_GI...

Full description

Saved in:
Bibliographic Details
Published in:Journal of medical virology 2017-02, Vol.89 (2), p.363-367
Main Authors: Mori, Kohji, Chu, Pei‐Yu, Motomura, Kazushi, Somura, Yoshiko, Nagano, Miyuki, Kimoto, Kana, Akiba, Tetsuya, Kai, Akemi, Sadamasu, Kenji
Format: Article
Language:English
Subjects:
Amino Acid Substitution
Amino acids
Caliciviridae Infections - epidemiology
Caliciviridae Infections - virology
Evolution
Evolution, Molecular
genetic variability
Genomics
Genotype
Humans
Molecular Epidemiology
mutation
Norovirus
Norovirus - classification
Norovirus - genetics
Norovirus - isolation & purification
recombination
Recombination, Genetic
Sequence Analysis, DNA
Tokyo - epidemiology
Virology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study aimed to analyze NoV GII.4 sequences from archival specimens obtained during 1975–1987 by comparing them with reference sequences. The first NoV GII.P4_GII.4 sequence was identified in 1980. NoV GII.4 collected in 1970 had a GII.P1_GII.4 sequence. These results indicate that the GII.P4_GII.4 sequence may be the result of a recombination that might have occurred around 1980. Amino acid substitutions based on this replacement were mainly accumulated in the NTPase, p22, and RdRp regions. The emergence of GII.P4_GII.4 sequence is considered to have ended the major prevalence of NoV GII.4. J. Med. Virol. 89:363–367, 2017. © 2016 Wiley Periodicals, Inc.
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.24624