Splenic infarction associated with acute infectious mononucleosis due to Epstein–Barr virus infection

The purpose of this study was to report a case of a previously healthy 20‐year‐old woman diagnosed with splenic infarction following infectious mononucleosis (IM) by Epstein–Barr virus (EBV) infection and to perform the first systematic review of the clinical characteristics of splenic infarction as...

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Bibliographic Details
Published in:Journal of medical virology 2017-02, Vol.89 (2), p.332-336
Main Authors: Heo, Dae‐Hyuk, Baek, Dae‐Youb, Oh, Sang‐Min, Hwang, Joo‐Hee, Lee, Chang‐Seop, Hwang, Jeong‐Hwan
Format: Article
Language:English
Subjects:
Adolescent
Adult
Child
Epidemiology
Epstein-Barr virus
Female
Herpesvirus 4, Human - isolation & purification
Humans
infectious mononucleosis
Infectious Mononucleosis - complications
Infectious Mononucleosis - diagnosis
Male
Middle Aged
Spleen
splenic infarction
Splenic Infarction - etiology
Splenic Infarction - pathology
Viral infections
Virology
Young Adult
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Summary:The purpose of this study was to report a case of a previously healthy 20‐year‐old woman diagnosed with splenic infarction following infectious mononucleosis (IM) by Epstein–Barr virus (EBV) infection and to perform the first systematic review of the clinical characteristics of splenic infarction associated with IM. A systematic review was conducted using English, French, and Japanese literatures of splenic infarction associated with IM due to EBV infection published between 1961 and 2015 in PubMed Medline. A total of 19 cases were extracted from the collected articles. Left upper quadrant (LUQ) pain was observed in 15 (79%) patients. Splenectomy was performed in five (26%) cases, among which four patients presented with stable vital signs. Splenic rupture was accompanied in two (10%) patients. The median time from the onset of IM symptoms to the diagnosis of splenic infarction was 5 days (range, 1–25 days). Fourteen (74%) of 19 patients experienced improvement through medical treatment, and there were no deaths. Splenic infarction associated with IM due to EBV infection can show a favorable clinical outcome after medical treatment. Clinicians should consider the possibility of splenic infarction when patients with IM experience LUQ pain. J. Med. Virol. 89:332–336, 2017. © 2016 Wiley Periodicals, Inc.
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.24618