Huge hepatocellular carcinoma greater than 10 cm in diameter worsens prognosis by causing distant recurrence after curative resection

Background and Objectives This study aimed to evaluate the impact of huge (≥10 cm) hepatocellular carcinoma (HCC) to the recurrence pattern and the prognosis after hepatectomy. Methods 574 patients who underwent hepatectomy by 17 surgeons (Open 536 and Laparoscopic 38) for HCC without major vascular...

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Bibliographic Details
Published in:Journal of surgical oncology 2017-03, Vol.115 (3), p.324-329
Main Authors: Wakayama, Kenji, Kamiyama, Toshiya, Yokoo, Hideki, Orimo, Tatsuya, Shimada, Shingo, Einama, Takahiro, Kamachi, Hirofumi, Taketomi, Akinobu
Format: Article
Language:English
Subjects:
Carcinoma, Hepatocellular - blood supply
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - surgery
Cohort Studies
Female
Hepatectomy
hepatic resection
hepatocellular carcinoma
huge
Humans
Liver Neoplasms - blood supply
Liver Neoplasms - pathology
Liver Neoplasms - surgery
Male
Middle Aged
Neoplasm Recurrence, Local - pathology
Neoplasm Staging
overall survival
Prognosis
relapse‐free survival
Retrospective Studies
Survival Rate
Treatment Outcome
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Summary:Background and Objectives This study aimed to evaluate the impact of huge (≥10 cm) hepatocellular carcinoma (HCC) to the recurrence pattern and the prognosis after hepatectomy. Methods 574 patients who underwent hepatectomy by 17 surgeons (Open 536 and Laparoscopic 38) for HCC without major vascular invasion from 1990 to 2013 at single institute were retrospectively analyzed. Results Huge tumor, age, HCV, multiple tumors and microscopic portal invasion are independent risk factors for overall survival (OS), and huge tumor, ICGR15 ≥16%, multiple tumors, moderate/poor histology, microscopic portal invasion and a positive pathological margin are risk factors for relapse‐free survival (RFS). The 5‐year OS and RFS of patients with huge HCC (n = 53) (42.9 and 14.2%) were significantly worse than those of patients with HCC
ISSN:0022-4790
1096-9098
DOI:10.1002/jso.24501