Effect of harvest time on some in vitro functional properties of hop polyphenols

•Hop polyphenols (HPP) from Saaz variety harvested at different times were analyzed.•Some in vitro functional properties of HPP were assessed.•HPP from early harvested samples caused increase in anti-adipocyte differentiation.•Anti-NO production activity significantly varied in different harvest yea...

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Bibliographic Details
Published in:Food chemistry 2017-06, Vol.225, p.69-76
Main Authors: Inui, Takako, Okumura, Koharu, Matsui, Hiroo, Hosoya, Takahiro, Kumazawa, Shigenori
Format: Article
Language:English
Subjects:
Adipocytes - drug effects
Adipocytes - physiology
Animals
Anti-adipocyte differentiation
Anti-NO production
Antioxidant
Antioxidants - analysis
Antioxidants - pharmacology
Cell Differentiation
Crop Production
Harvest time
Harvest year
Hop polyphenols
Humulus - chemistry
Mice
Polyphenols - analysis
Polyphenols - pharmacology
Saaz
Seasons
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Summary:•Hop polyphenols (HPP) from Saaz variety harvested at different times were analyzed.•Some in vitro functional properties of HPP were assessed.•HPP from early harvested samples caused increase in anti-adipocyte differentiation.•Anti-NO production activity significantly varied in different harvest years. Health benefits of hop polyphenols are well studied. In the present investigation, we examined the antioxidant activity, anti-nitric oxide (NO) production, and anti-adipocyte differentiation of polyphenols extracted from hops (HPP), harvested at different times for over 4years. Saaz hop variety from the Czech Republic was used in the in vitro assays. Twenty-three polyphenols were quantitatively analyzed using Orbitrap liquid chromatography–mass spectrometry (LC–MS), and their health promoting effects were assayed individually. Strong effects of low concentrations of HPP were observed in the above three assays. A significant increase in anti-adipocyte differentiation activity per unit weight of HPP was obtained in the early harvested samples. A significant difference in anti-NO production activity per unit weight of HPP was observed among the different harvest years. HPP significantly increased in early harvested samples. Our results suggest that some in vitro functional properties of hops vary with harvest time and year and are dependent on different polyphenols.
ISSN:0308-8146
1873-7072
DOI:10.1016/j.foodchem.2017.01.002