Effects of vaccine-acquired polyclonal anti-HBs antibodies on the prevention of HBV infection of non-vaccine genotypes

Background In universal hepatitis B (HB) vaccination, single vaccine-derived polyclonal anti-HBs antibodies (anti-HBs) need to inhibit infection of HB viruses (HBV) of non-vaccine genotypes. We experimentally addressed this issue. Methods Anti-HBs-positive sera were obtained by vaccination with geno...

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Bibliographic Details
Published in:Journal of gastroenterology 2017-09, Vol.52 (9), p.1051-1063
Main Authors: Kato, Masaki, Hamada-Tsutsumi, Susumu, Okuse, Chiaki, Sakai, Aiko, Matsumoto, Nobuyuki, Sato, Masaaki, Sato, Toshiyuki, Arito, Mitsumi, Omoteyama, Kazuki, Suematsu, Naoya, Okamoto, Kazuki, Kato, Takanobu, Itoh, Fumio, Sumazaki, Ryo, Tanaka, Yasuhito, Yotsuyanagi, Hiroshi, Kato, Tomohiro, Kurokawa, Manae Suzuki
Format: Article
Language:English
Subjects:
Abdominal Surgery
Adolescent
Adult
Analysis
Antibodies
Antigen-antibody reactions
Antigens
Biliary Tract
Colorectal Surgery
Enzyme-Linked Immunosorbent Assay
Female
Gastroenterology
Genetic aspects
Genotype
Genotype & phenotype
Genotypes
Hepatitis B
Hepatitis B - immunology
Hepatitis B - prevention & control
Hepatitis B Antibodies - blood
Hepatitis B surface antigen
Hepatitis B Surface Antigens - blood
Hepatitis B Vaccines - administration & dosage
Hepatitis B Vaccines - immunology
Hepatitis B virus - genetics
Hepatitis B virus - immunology
Hepatology
Humans
Immunization
Infections
Male
Medicine
Medicine & Public Health
Original Article—Liver
Pancreas
Surgical Oncology
Vaccination
Vaccines
Young Adult
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Summary:Background In universal hepatitis B (HB) vaccination, single vaccine-derived polyclonal anti-HBs antibodies (anti-HBs) need to inhibit infection of HB viruses (HBV) of non-vaccine genotypes. We experimentally addressed this issue. Methods Anti-HBs-positive sera were obtained by vaccination with genotype A- or C-derived HBs antigen (HBsAg, gtA-sera or gtC-sera). Their reactivity to genotype A- and C-derived HBsAg (gtA-Ag and gtC-Ag) was measured by ELISA. The capacity of sera to neutralize HBV was evaluated using an in vitro infection model. Results Of 135 anti-gtA-Ag-reactive gtA-sera, 134 (99.3%) were anti-gtC-Ag-reactive. All (100%) 120 anti-gtC-Ag-reactive gtC-sera were anti-gtA-Ag-reactive. The reactivity to gtA-Ag was strongly correlated with that to gtC-Ag (gtA-sera, ρ  = 0.989; gtC-sera, ρ  = 0.953; p  
ISSN:0944-1174
1435-5922
DOI:10.1007/s00535-017-1316-3