The First Biocatalytic Carbon–Silicon Bond Formation

Linking two worlds: As a further expansion of the biocatalytic repertoire, carbene insertion into Si−H bonds catalyzed by the heme protein cytochrome c was recently reported. This new biocatalyst holds great promise because it enables the highly selective incorporation of silicon into molecules with...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2017-03, Vol.56 (12), p.3140-3141
Main Author: Lutz, Stephan
Format: Article
Language:English
Subjects:
biocatalysis
biotransformations
cytochrome P450
enzymes
protein engineering
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Summary:Linking two worlds: As a further expansion of the biocatalytic repertoire, carbene insertion into Si−H bonds catalyzed by the heme protein cytochrome c was recently reported. This new biocatalyst holds great promise because it enables the highly selective incorporation of silicon into molecules without prior protection of existing functional groups.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201612543