Gardnerella vaginalis population dynamics in bacterial vaginosis

Bacterial vaginosis (BV) is the leading cause of vaginal discharge and is associated with the facultative Gram-variable bacterium Gardnerella vaginalis , whose population structure consists of four clades. Our goal was to determine if these clades differ with regard to abundance during BV. We perfor...

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Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 2017-07, Vol.36 (7), p.1269-1278
Main Authors: Hilbert, D. W., Schuyler, J. A., Adelson, M. E., Mordechai, E., Sobel, J. D., Gygax, S. E.
Format: Article
Language:English
Subjects:
Abundance
Adolescent
Adult
Bacteria
Bacterial Load
Biomedical and Life Sciences
Biomedicine
Chains (polymeric)
Correlation analysis
Criteria
Dysbacteriosis
Female
Gardnerella vaginalis - classification
Gardnerella vaginalis - genetics
Gardnerella vaginalis - growth & development
Genotype
Humans
Internal Medicine
Longitudinal Studies
Medical Microbiology
Middle Aged
Original Article
Polymerase chain reaction
Population Dynamics
Population structure
Real-Time Polymerase Chain Reaction
Vagina
Vaginosis
Vaginosis, Bacterial - microbiology
Young Adult
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Summary:Bacterial vaginosis (BV) is the leading cause of vaginal discharge and is associated with the facultative Gram-variable bacterium Gardnerella vaginalis , whose population structure consists of four clades. Our goal was to determine if these clades differ with regard to abundance during BV. We performed a short-term longitudinal study of BV. Patients were evaluated according to the Amsel criteria and Nugent scoring at initial diagnosis, immediately after treatment and at a 40- to 45-day follow-up visit. G. vaginalis clade abundance was determined by quantitative real-time polymerase chain reactions (qPCRs). Among all specimens, the abundance of clades 1 and 4 were higher than that of clades 2 and 3 ( P  
ISSN:0934-9723
1435-4373
DOI:10.1007/s10096-017-2933-8