Perioperative morbidity, oncological outcomes and predictors of pT3a upstaging for patients undergoing partial nephrectomy for cT1 tumors

Objectives To evaluate perioperative morbidity, oncological outcome and predictors of pT3a upstaging after partial nephrectomy (PN). Materials and methods Retrospective study of 1042 patients who underwent PN for cT1N0M0 renal cell carcinoma between 2007 and 2015. A total of 113 cT1 patients were up...

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Bibliographic Details
Published in:World journal of urology 2017-09, Vol.35 (9), p.1425-1433
Main Authors: Mouracade, Pascal, Kara, Onder, Dagenais, Julien, Maurice, M. J., Nelson, R. J., Malkoc, Ercan, Kaouk, J. H.
Format: Article
Language:English
Subjects:
Aged
Blood Loss, Surgical
Blood transfusion
Blood Transfusion - utilization
Carcinoma, Renal Cell - pathology
Carcinoma, Renal Cell - surgery
Cold Ischemia - statistics & numerical data
Disease-Free Survival
Female
Glomerular Filtration Rate
Humans
Ischemia
Kidney cancer
Kidney Neoplasms - pathology
Kidney Neoplasms - surgery
Kidney transplantation
Logistic Models
Male
Medicine
Medicine & Public Health
Middle Aged
Morbidity
Multivariate Analysis
Neoplasm Staging
Nephrectomy
Nephrology
Oncology
Original Article
Patient Readmission - statistics & numerical data
Perioperative Period
Postoperative Complications - epidemiology
Renal cell carcinoma
Renal Insufficiency - epidemiology
Reoperation
Retrospective Studies
Risk Factors
Sex Factors
Survival
Survival Analysis
Treatment Outcome
Tumors
Urology
Warm Ischemia - statistics & numerical data
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Summary:Objectives To evaluate perioperative morbidity, oncological outcome and predictors of pT3a upstaging after partial nephrectomy (PN). Materials and methods Retrospective study of 1042 patients who underwent PN for cT1N0M0 renal cell carcinoma between 2007 and 2015. A total of 113 cT1 patients were upstaged to pT3a, while 929 were staged as pT1. Demographic, perioperative and pathological variables were reviewed. We compared the clinico-pathological characteristics, perioperative morbidity and oncological outcomes between pT3a and pT1 groups. Multivariate regression evaluates variables associated with T3a upstaging. Recurrence-free survival (RFS) and overall survival analyses were performed. Survival curves were compared using log-rank test. Results The pT3a tumors were high complexity tumors (median RENAL score 8 vs. 7, p  
ISSN:0724-4983
1433-8726
DOI:10.1007/s00345-017-2004-x