Targeting of plant-derived vaccine antigens to immunoresponsive mucosal sites

Most pathogenic microorganisms enter their host via the mucosal surfaces lining the digestive, respiratory and urino-reproductive tracts of the body. The most efficient means of protecting these surfaces is through mucosal immunization. Transgenic plants are safe and inexpensive vehicles to produce...

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Bibliographic Details
Published in:Vaccine 2003-01, Vol.21 (7), p.809-811
Main Authors: Rigano, M.Manuela, Sala, Francesco, Arntzen, Charles J, Walmsley, Amanda M
Format: Article
Language:English
Subjects:
Antigens - administration & dosage
Antigens - immunology
Bacterial Toxins - biosynthesis
Bacterial Toxins - genetics
Bacterial Toxins - immunology
Bacteriology
Biological and medical sciences
Cholera Toxin - biosynthesis
Cholera Toxin - genetics
Cholera Toxin - immunology
Drug Carriers
Drug Delivery Systems
E coli
Enterotoxins - biosynthesis
Enterotoxins - genetics
Enterotoxins - immunology
Escherichia coli - immunology
Escherichia coli Proteins
Food contamination & poisoning
Fundamental and applied biological sciences. Psychology
Gene Transfer Techniques
Humans
Immune system
Immunity, Mucosal - immunology
Immunization
Intestinal Mucosa - immunology
Microbiology
Microorganisms
Mucosal immune system
Plants, Genetically Modified - genetics
Plants, Genetically Modified - metabolism
Potatoes
Proteins
Recombinant Fusion Proteins - biosynthesis
Recombinant Fusion Proteins - genetics
Recombinant Fusion Proteins - immunology
Rodents
Transgenic plants
Tuberculosis
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
Vaccines, Subunit - administration & dosage
Vaccines, Subunit - immunology
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Summary:Most pathogenic microorganisms enter their host via the mucosal surfaces lining the digestive, respiratory and urino-reproductive tracts of the body. The most efficient means of protecting these surfaces is through mucosal immunization. Transgenic plants are safe and inexpensive vehicles to produce and mucosally deliver protective antigens. However, the application of this technology is limited by the poor response of the immune system to non-particulate, subunit vaccines. Co-delivery of therapeutic proteins with targeting proteins, such as the B subunit of the Escherichia coli heat labile enterotoxin (LTB), could increase the effectiveness of such antigens.
ISSN:0264-410X
1873-2518
DOI:10.1016/S0264-410X(02)00604-7