Association between brain-derived neurotrophic factor and severity of asthma in children

To investigate the association between the serum level of brain-derived neurotrophic factor (BDNF) and the severity of asthma in children. A total of 60 children with acute exacerbation of asthma were enrolled and divided according to the severity of the disease into mild group (n=18), moderate grou...

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Bibliographic Details
Published in:Zhongguo dang dai er ke za zhi 2017-02, Vol.19 (2), p.167
Main Authors: Feng, Shuai, Chen, Bo, Yin, Xiao-Wen, Li, Fang-Jun
Format: Article
Language:Chinese
Subjects:
Adolescent
Asthma - blood
Asthma - etiology
Brain-Derived Neurotrophic Factor - blood
Child
Child, Preschool
Female
Humans
Infant
Male
Severity of Illness Index
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Summary:To investigate the association between the serum level of brain-derived neurotrophic factor (BDNF) and the severity of asthma in children. A total of 60 children with acute exacerbation of asthma were enrolled and divided according to the severity of the disease into mild group (n=18), moderate group (n=25), and severe group (n=17). Sixty healthy children were enrolled as controls. ELISA was used to measure the serum BDNF level in each group and the association between serum BDNF level and the severity of asthma was analyzed. The asthmatic children at the acute exacerbation and remission stages had significantly higher serum BDNF levels than healthy controls (P
ISSN:1008-8830
DOI:10.7499/j.issn.1008-8830.2017.02.008