Alleviation of Ischaemia-reperfusion Injury by Endogenous Estrogen Involves Maintaining Bcl-2 Expression via the ERα Signalling Pathway

Highlights • Letrozole (aromatase inhibitor) treatment significantly aggravated cerebral ischemia-reperfusion injury by decreasing endogenous estrogen production. • Endogenous estrogen alleviates ischaemia-reperfusion injury by maintaining Bcl-2 expression via the ERα signalling pathway. • We sugges...

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Bibliographic Details
Published in:Brain research 2017-04, Vol.1661, p.15-23
Main Authors: Zhang, Zeng-li, Qin, Pei, Liu, Yuhong, Zhang, Li-xia, Guo, Hang, Deng, You-liang, Yizhao-Liu, Hou, Yu-shu, Wang, Li-yang, Miao, Yi, Ma, Yu-long, Hou, Wu-gang
Format: Article
Language:English
Subjects:
Animals
Apoptosis - drug effects
Brain - metabolism
Brain Ischemia - metabolism
Cerebral ischaemia
Endogenous estrogen
Estradiol - pharmacology
Estrogen Receptor alpha - metabolism
Estrogens - pharmacology
Estrogens - therapeutic use
Estrous cycle
Estrous Cycle - drug effects
Estrous Cycle - physiology
Female
Genes, bcl-2 - drug effects
Infarction, Middle Cerebral Artery - metabolism
Neurology
Neurons - metabolism
Neuroprotection
Neuroprotective Agents - pharmacology
Nitriles
Ovariectomy
Rats
Rats, Sprague-Dawley
Reperfusion Injury - drug therapy
Signal Transduction
Triazoles
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Summary:Highlights • Letrozole (aromatase inhibitor) treatment significantly aggravated cerebral ischemia-reperfusion injury by decreasing endogenous estrogen production. • Endogenous estrogen alleviates ischaemia-reperfusion injury by maintaining Bcl-2 expression via the ERα signalling pathway. • We suggest researchers use female animals in the diestrous phase of estrous cycle as a control group to avoid the variations in results induced by the fluctuation of circulating estrogen levels.
ISSN:0006-8993
1872-6240
DOI:10.1016/j.brainres.2017.02.004