Improved Postoperative Survival for Intraductal- Growth Subtype of Intrahepatic Cholangiocarcinoma

Intrahepatic cholangiocarcinoma (ICC) is classified according to the following subtypes: mass-forming (MF), periductal infiltrating (PI), and intraductal growth (IG). The aim of this study is to measure the association between ICC subtypes and patient survival after surgical resection. Data were abs...

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Bibliographic Details
Published in:The American surgeon 2016-11, Vol.82 (11), p.1133-1139
Main Authors: Dover, Laura L., Jacob, Rojymon, Wang, Thomas N., Richardson, Joseph H., Redden, David T., Li, Peng, Dubay, Derek A.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Bile
Bile Duct Neoplasms - diagnostic imaging
Bile Duct Neoplasms - mortality
Bile Duct Neoplasms - pathology
Bile Duct Neoplasms - surgery
Cancer therapies
Chemotherapy
Cholangiocarcinoma - diagnostic imaging
Cholangiocarcinoma - mortality
Cholangiocarcinoma - pathology
Cholangiocarcinoma - surgery
Disease-Free Survival
Female
Hepatectomy - methods
Hepatectomy - mortality
Humans
Kaplan-Meier Estimate
Liver cancer
Male
Medical prognosis
Metastasis
Middle Aged
Morphology
Mortality
Mutation
Neoplasm Invasiveness
Patients
Postoperative Period
Studies
Tomography, X-Ray Computed
Tumors
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Summary:Intrahepatic cholangiocarcinoma (ICC) is classified according to the following subtypes: mass-forming (MF), periductal infiltrating (PI), and intraductal growth (IG). The aim of this study is to measure the association between ICC subtypes and patient survival after surgical resection. Data were abstracted on all patients treated with definitive resections of ICC at a single institution between 2000 and 2011 with at least three years follow-up. Survival estimates were quantified using Kaplan-Meier curves and compared using the log-rank test. There were 37 patients with ICC treated with definitive partial hepatectomies with a median survival of 33.5 months. Tumor stage (P < 0.0001), satellitosis (P < 0.001), lymphovascular space invasion (P = 0.003), and macroscopic subtype (P = 0.003) were predictive of postoperative survival. Disease-free survivals for MF, PI, and IG subtypes, respectively, were 30 per cent, 0 per cent, and 57 per cent (P = 0.017). Overall survivals among ICC macroscopic subtypes were as follows: MF 37 per cent, PI 0 per cent, and IG 71 per cent (P = 0.003). Although limited by the small sample size of this rare cancer, this study demonstrates significant differences among macroscopic subtypes of ICC in both disease-free survivals and overall survivals after definitive partial hepatectomy.
ISSN:0003-1348
1555-9823
DOI:10.1177/000313481608201132