HBVcircle: A novel tool to investigate hepatitis B virus covalently closed circular DNA

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Bibliographic Details
Published in:Journal of hepatology 2017-06, Vol.66 (6), p.1149-1157
Main Authors: Yan, Zhipeng, Zeng, Jing, Yu, Youjun, Xiang, Kunlun, Hu, Hui, Zhou, Xue, Gu, Lili, Wang, Li, Zhao, Jie, Young, John A.T, Gao, Lu
Format: Article
Language:English
Subjects:
Adaptive Immunity
Animal models
Animals
Anti-HBV drug discovery
Cell culture
Cell Line
Circular DNA
DNA, Circular - biosynthesis
DNA, Circular - genetics
DNA, Circular - immunology
DNA, Viral - biosynthesis
DNA, Viral - genetics
DNA, Viral - immunology
Drug development
Drug Discovery
Drug Evaluation, Preclinical
Drug screening
Expression vectors
Gastroenterology and Hepatology
Gene expression
Genes, Viral
Genetic Engineering
Genetic recombination
Genetic Techniques
Genomes
Genotypes
HBV mouse model
Hep G2 Cells
Hepatitis
Hepatitis B
Hepatitis B - drug therapy
Hepatitis B - virology
Hepatitis B virus - genetics
Hepatitis B virus - immunology
Hepatitis B virus - physiology
Hepatocytes
Hepatocytes - virology
Host range
Humans
Hydrodynamic injection
Immune response
Immunosuppressive agents
Liver
Male
Mice
Mice, Inbred C3H
Minicircle
Models, Genetic
Phenotypes
Recombinant cccDNA
Replication
Transcription
Transcription, Genetic
Transfection
Vectors (Biology)
Virus Replication - genetics
Viruses
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Description
Summary:Graphical abstract
ISSN:0168-8278
1600-0641
DOI:10.1016/j.jhep.2017.02.004