Analysis of a panel of druggable gene mutations and of ALK and PD-L1 expression in a series of thymic epithelial tumors (TETs)

Highlights • Thymic epithelial tumors (TETs) are rare neoplasms with different prognosis. • The identification of new targets an emerging need in TET management. • A panel of 7 druggable genes and ALK and PD-L1 expression were evaluated. • Thymic carcinoma can harbor c-KIT mutations and elevated PD-...

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Published in:Lung cancer (Amsterdam, Netherlands) Netherlands), 2017-02, Vol.104, p.24-30
Main Authors: Tiseo, Marcello, Damato, Angela, Longo, Lucia, Barbieri, Fausto, Bertolini, Federica, Stefani, Alessandro, Migaldi, Mario, Gnetti, Letizia, Camisa, Roberta, Bordi, Paola, Buti, Sebastiano, Rossi, Giulio
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
B7-H1 Antigen - metabolism
c-KIT
Female
Gene mutations
Hematology, Oncology and Palliative Medicine
Humans
Male
Middle Aged
Mutation
Neoplasm Staging
Neoplasms, Glandular and Epithelial - metabolism
Neoplasms, Glandular and Epithelial - pathology
PD-L1
Proto-Oncogene Proteins c-kit - metabolism
Pulmonary/Respiratory
Receptor Protein-Tyrosine Kinases - metabolism
Retrospective Studies
Survival Analysis
Thymic carcinoma
Thymoma
Thymoma - metabolism
Thymoma - pathology
Thymus Gland - metabolism
Thymus Gland - pathology
Thymus Neoplasms - metabolism
Thymus Neoplasms - pathology
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container_title Lung cancer (Amsterdam, Netherlands)
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creator Tiseo, Marcello
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Longo, Lucia
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Camisa, Roberta
Bordi, Paola
Buti, Sebastiano
Rossi, Giulio
description Highlights • Thymic epithelial tumors (TETs) are rare neoplasms with different prognosis. • The identification of new targets an emerging need in TET management. • A panel of 7 druggable genes and ALK and PD-L1 expression were evaluated. • Thymic carcinoma can harbor c-KIT mutations and elevated PD-L1 expression. • c-KIT mutations and PD-L1 could represent targets of potential therapeutic use.
doi_str_mv 10.1016/j.lungcan.2016.12.005
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ispartof Lung cancer (Amsterdam, Netherlands), 2017-02, Vol.104, p.24-30
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1872-8332
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source ScienceDirect Journals
subjects Adult
Aged
Aged, 80 and over
B7-H1 Antigen - metabolism
c-KIT
Female
Gene mutations
Hematology, Oncology and Palliative Medicine
Humans
Male
Middle Aged
Mutation
Neoplasm Staging
Neoplasms, Glandular and Epithelial - metabolism
Neoplasms, Glandular and Epithelial - pathology
PD-L1
Proto-Oncogene Proteins c-kit - metabolism
Pulmonary/Respiratory
Receptor Protein-Tyrosine Kinases - metabolism
Retrospective Studies
Survival Analysis
Thymic carcinoma
Thymoma
Thymoma - metabolism
Thymoma - pathology
Thymus Gland - metabolism
Thymus Gland - pathology
Thymus Neoplasms - metabolism
Thymus Neoplasms - pathology
title Analysis of a panel of druggable gene mutations and of ALK and PD-L1 expression in a series of thymic epithelial tumors (TETs)
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