The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44

We have characterized a cluster of single immunoglobulin variable (IgV) domain receptors centromeric of the major histocompatibility complex (MHC) on human chromosome 6. In addition to triggering receptor expressed on myeloid cells (TREM)‐1 and TREM2, the cluster contains NKp44, a triggering recepto...

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Bibliographic Details
Published in:European journal of immunology 2003-02, Vol.33 (2), p.567-577
Main Authors: Allcock, Richard J. N., Barrow, Alexander D., Forbes, Simon, Beck, Stephan, Trowsdale, John
Format: Article
Language:English
Subjects:
Activation
Amino Acid Motifs
Amino Acid Sequence
Animals
Chromosome Mapping
Chromosomes, Human, Pair 6 - genetics
Evolution, Molecular
Exons - genetics
Expressed Sequence Tags
Gene Expression Regulation
Genomics
Glycosylation
Humans
Immunoglobulin superfamily
Immunoglobulin Variable Region - genetics
Inhibition
Introns - genetics
Long Interspersed Nucleotide Elements
Membrane Glycoproteins
Mice
Molecular Sequence Data
Multigene Family
Natural Cytotoxicity Triggering Receptor 2
Phylogeny
Protein Structure, Tertiary
Pseudogenes - genetics
Receptors, Immunologic - genetics
RNA, Messenger - genetics
Sequence Alignment
Sequence Homology, Amino Acid
Species Specificity
TREM
Triggering Receptor Expressed on Myeloid Cells-1
U937 Cells - chemistry
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Description
Summary:We have characterized a cluster of single immunoglobulin variable (IgV) domain receptors centromeric of the major histocompatibility complex (MHC) on human chromosome 6. In addition to triggering receptor expressed on myeloid cells (TREM)‐1 and TREM2, the cluster contains NKp44, a triggering receptor whose expression is limited to NK cells. We identified three new related genes and two gene fragments within a cluster of ∼200 kb. Two of the three new genes lack charged residues in their transmembrane domain tails. Further, one of the genes contains two potential immunotyrosine inhibitory motifs in its cytoplasmic tail, suggesting that it delivers inhibitory signals. The human and mouse TREM clusters appear to have diverged such that there are unique sequences in each species. Finally, each gene in the TREM cluster was expressed in a different range of cell types.
ISSN:0014-2980
1521-4141
DOI:10.1002/immu.200310033