Cerebral small vessel disease predisposes to temporal lobe epilepsy in spontaneously hypertensive rats

Highlights • 5-weeks-old spontaneously hypertensive rats (SHRs) have similar seizure susceptibility to control rats. • 16-weeks-old SHRs develop amygdala kindling more rapidly (less stimulations) than control rats. • 16-weeks-old SHRs display cerebral small vessels disease (CSVD) which is prevented...

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Bibliographic Details
Published in:Brain research bulletin 2017-04, Vol.130, p.245-250
Main Authors: Russo, Emilio, Leo, Antonio, Scicchitano, Francesca, Donato, Annalidia, Ferlazzo, Edoardo, Gasparini, Sara, Cianci, Vittoria, Mignogna, Chiara, Donato, Giuseppe, Citraro, Rita, Aguglia, Umberto, De Sarro, Giovambattista
Format: Article
Language:English
Subjects:
Amygdala - physiopathology
Animals
Cerebral Small Vessel Diseases - complications
Cerebral Small Vessel Diseases - physiopathology
Electric Stimulation
Epilepsy, Temporal Lobe - complications
Epilepsy, Temporal Lobe - physiopathology
Hypertension
Kindling
Male
Neurology
Pentylenetetrazole
Rats, Inbred SHR
Rats, Inbred WKY
Seizures - complications
Seizures - physiopathology
SHRs
Species Specificity
Stroke
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Summary:Highlights • 5-weeks-old spontaneously hypertensive rats (SHRs) have similar seizure susceptibility to control rats. • 16-weeks-old SHRs develop amygdala kindling more rapidly (less stimulations) than control rats. • 16-weeks-old SHRs display cerebral small vessels disease (CSVD) which is prevented by enalapril long-term treatment. • Enalapril treatment, inhibiting the development of CSVD, normalizes amygdala kindling development in SHRs. • CSVD in SHRs is associated with a higher susceptibility to amygdala kindling.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2017.02.003