Mitochondrial genotype modulates mtDNA copy number and organismal phenotype in Drosophila

We evaluated the role of natural mitochondrial DNA (mtDNA) variation on mtDNA copy number, biochemical features and life history traits in Drosophila cybrid strains. We demonstrate the effects of both coding region and non-coding A+T region variation on mtDNA copy number, and demonstrate that copy n...

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Bibliographic Details
Published in:Mitochondrion 2017-05, Vol.34, p.75-83
Main Authors: Salminen, Tiina S, Oliveira, Marcos T, Cannino, Giuseppe, Lillsunde, Päivi, Jacobs, Howard T, Kaguni, Laurie S
Format: Article
Language:English
Subjects:
Animals
Cell Respiration
DNA, Mitochondrial - genetics
Drosophila - genetics
Drosophila - physiology
Female
Gene Dosage
Genotype
Male
Mitochondria - genetics
Mitochondria - metabolism
Oxidative Phosphorylation
Phenotype
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Summary:We evaluated the role of natural mitochondrial DNA (mtDNA) variation on mtDNA copy number, biochemical features and life history traits in Drosophila cybrid strains. We demonstrate the effects of both coding region and non-coding A+T region variation on mtDNA copy number, and demonstrate that copy number correlates with mitochondrial biochemistry and metabolically important traits such as development time. For example, high mtDNA copy number correlates with longer development times. Our findings support the hypothesis that mtDNA copy number is modulated by mtDNA genome variation and suggest that it affects OXPHOS efficiency through changes in the organization of the respiratory membrane complexes to influence organismal phenotype.
ISSN:1567-7249
1872-8278
DOI:10.1016/j.mito.2017.02.001