Serum levels of homocysteine at admission are associated with post-stroke depression in acute ischemic stroke

• Published in: Neurological sciences 2017-05, Vol.38 (5), p.811-817
• Main Authors: Li, Yan, Cao, Li-Li, Liu, Lin, Qi, Qin-De
• Format: Article
• Language: English
• Subjects: Aged; Brain Ischemia - complications; Depression - blood; Depression - etiology; Female; Follow-Up Studies; Health risk assessment; Homocysteine; Homocysteine - blood; Humans; Ischemia; Magnetic Resonance Imaging; Male; Medicine; Medicine & Public Health; Mental depression; Middle Aged; Neurology; Neuroradiology; Neurosciences; Neurosurgery; Original Article; Patient Admission; Psychiatric Status Rating Scales; Psychiatry; ROC Curve; Serum levels; Statistics, Nonparametric; Stroke; Stroke - complications; Stroke - diagnostic imaging; Stroke - etiology; Tomography, X-Ray Computed
• ISSN: 1590-1874; 1590-3478
• DOI: 10.1007/s10072-017-2848-2

The primary purpose of this study was to assess the serum levels of homocysteine (HCY) at admission to the presence of post-stroke depression (PSD). From September 2014 to December 2015, first-ever acute ischemic stroke patients within the first 24 h after stroke onset were consecutively recruited and followed-up for 3 months. Based on the symptoms, diagnoses of depression were made in accordance with DSM-IV criteria for depression. By the time of 3 month after stroke, 238 had finished the follow-up and included in our study. Totally, 65 out of the 238 patients were diagnosed as depression (27.3%; 95% CI 19.6–35.4%). The results showed significantly higher HCY levels in patients with depression [21.4 (IQR 16.5–23.4) mmol/L vs. 14.1 (IQR 11.2–18.5) mmol/L, P