Left atrial appendage occlusion: Fighting the “dark side” of atrial fibrillation

Key points In this real world UK retrospective experience LAAO confirms its safety profile with one procedure related death (0.25%), and 3.5% incidence of major adverse events. There is a significant learning curve effect (acute major events were reduced from 6.5 to 0.5% between first and second hal...

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Bibliographic Details
Published in:Catheterization and cardiovascular interventions 2017-02, Vol.89 (3), p.493-494
Main Authors: Meucci, Francesco, Di Mario, Carlo
Format: Article
Language:English
Subjects:
Atrial Appendage
Atrial Fibrillation
Echocardiography, Transesophageal
Humans
Stroke
Treatment Outcome
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Summary:Key points In this real world UK retrospective experience LAAO confirms its safety profile with one procedure related death (0.25%), and 3.5% incidence of major adverse events. There is a significant learning curve effect (acute major events were reduced from 6.5 to 0.5% between first and second half of enrollment) The two most widely used devices (Watchman and Amplatzer) did not differ in terms of safety and efficacy in immediate success (95%) and late reduction of expected ischemic events, confirming a class effect of LAAO therapy In a rapidly changing environment, further research is needed to understand whether LAAO should remain confined to a niche group with absolute contraindications to OAT or can be extended to patients at high bleeding risk with both VKA and NOACs.
ISSN:1522-1946
1522-726X
DOI:10.1002/ccd.26944