Transition-Metal-Catalyzed C–H Alkylation Using Alkenes

Alkylation reactions represent an important organic transformation to form C–C bonds. In addition to conventional approaches with alkyl halides or sulfonates as alkylating agents, the use of unactivated olefins for alkylations has become attractive from both cost and sustainability viewpoints. This...

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Bibliographic Details
Published in:Chemical reviews 2017-07, Vol.117 (13), p.9333-9403
Main Authors: Dong, Zhe, Ren, Zhi, Thompson, Samuel J, Xu, Yan, Dong, Guangbin
Format: Article
Language:English
Subjects:
Activation
Alkenes
Alkylation
Bonding
Carbon
Catalysis
Chemical reactions
Dienes
Halides
Hydrocarbons
Hydrogen bonds
Metals
Reagents
Sulfonates
Sustainability
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Summary:Alkylation reactions represent an important organic transformation to form C–C bonds. In addition to conventional approaches with alkyl halides or sulfonates as alkylating agents, the use of unactivated olefins for alkylations has become attractive from both cost and sustainability viewpoints. This Review summarizes transition-metal-catalyzed alkylations of various carbon–hydrogen bonds (addition of C–H bonds across olefins) using regular olefins or 1,3-dienes up to May 2016. According to the mode of activation, the Review is divided into two sections: alkylation via C–H activation and alkylation via olefin activation.
ISSN:0009-2665
1520-6890
DOI:10.1021/acs.chemrev.6b00574