Ru-Catalyzed Regioselective Direct Hydroxymethylation of (Hetero)Arenes via C–H Activation

An efficient and direct ruthenium-catalyzed regioselective hydroxymethylation of (hetero)­arenes via C–H activation with paraformaldehyde as a hydroxymethylating reagent is described. The corresponding products can be obtained in good to excellent yield. A number of aryl aldehydes can also be used i...

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Bibliographic Details
Published in:Organic letters 2017-03, Vol.19 (5), p.1216-1219
Main Authors: Zhang, Guo-Fu, Li, Yue, Xie, Xiao-Qiang, Ding, Cheng-Rong
Format: Article
Language:English
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Summary:An efficient and direct ruthenium-catalyzed regioselective hydroxymethylation of (hetero)­arenes via C–H activation with paraformaldehyde as a hydroxymethylating reagent is described. The corresponding products can be obtained in good to excellent yield. A number of aryl aldehydes can also be used in place of paraformaldehyde giving the desired alcohol products with similarly good results.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.7b00183