Evidence against the Presence of an Anandamide Transporter

On the basis of temperature dependency, saturability, selective inhibition, and substrate specificity, it has been proposed that an anandamide transporter exists. However, all of these studies have examined anandamide accumulation at long time points when downstream effects such as metabolism and in...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2003-04, Vol.100 (7), p.4269-4274
Main Authors: Glaser, Sherrye T., Abumrad, Nada A., Fatade, Folayan, Kaczocha, Martin, Studholme, Keith M., Deutsch, Dale G.
Format: Article
Language:English
Subjects:
Amides
Arachidonic Acids - pharmacokinetics
Astrocytoma
Biological Sciences
Biological Transport - drug effects
Cannabinoids - pharmacokinetics
Capsaicin - analogs & derivatives
Capsaicin - pharmacology
Carrier Proteins - metabolism
Cell membranes
Cells
Cellular metabolism
Endocannabinoids
Fatty acids
Humans
Hydrolysis
Immunohistochemistry
Kinetics
Membranes
Metabolism
Neuroblastoma
Neurons
Neurotransmitters
Polyunsaturated Alkamides
Tumor Cells, Cultured
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Summary:On the basis of temperature dependency, saturability, selective inhibition, and substrate specificity, it has been proposed that an anandamide transporter exists. However, all of these studies have examined anandamide accumulation at long time points when downstream effects such as metabolism and intracellular sequestration are operative. In the current study, we have investigated the initial rates (
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.0730816100