Streptenols F–I Isolated from the Marine-Derived Streptomyces misionensis BAT-10-03-023

A marine-derived bacterium, Streptomyces misionensis BAT-10-03-123, has produced four new streptenol derivatives, F, G, H, and I (1–4), as well as the known streptenols A and C (5 and 6). Their planar structures were elucidated by detailed analysis of spectroscopic data. The absolute configurations...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2017-04, Vol.80 (4), p.1034-1038
Main Authors: Tarazona, Guillermo, Schleissner, Carmen, Rodríguez, Pilar, Pérez, Marta, Cañedo, Librada M, Cuevas, Carmen
Format: Article
Language:English
Subjects:
Alkenes - chemistry
Alkenes - isolation & purification
Alkenes - pharmacology
Antineoplastic Agents - chemistry
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - pharmacology
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
HT29 Cells
Humans
Marine Biology
Microbial Sensitivity Tests
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Streptomyces - chemistry
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Summary:A marine-derived bacterium, Streptomyces misionensis BAT-10-03-123, has produced four new streptenol derivatives, F, G, H, and I (1–4), as well as the known streptenols A and C (5 and 6). Their planar structures were elucidated by detailed analysis of spectroscopic data. The absolute configurations of the new streptenol compounds were determined by chemical and spectroscopic methods, including Mosher’s ester method. All of the compounds were tested for cytotoxicity against four selected cancer cell lines.
ISSN:0163-3864
1520-6025
DOI:10.1021/acs.jnatprod.6b01057