Cardiovascular complications in paediatric-onset systemic lupus erythematosus in Saudi Arabian patients

• Published in: Clinical and experimental rheumatology 2017-05, Vol.35 (3), p.535-541
• Main Authors: Azhar, Ahmad S, Awlia, Omneyah Mohamed, Muzaffer, Mohammed A
• Format: Article
• Language: English
• Subjects: Adolescent; Age of Onset; Autoantibodies - blood; Biomarkers - blood; C-Reactive Protein - analysis; Child; Complement C3 - analysis; Complement C4 - analysis; Echocardiography; Electrocardiography; Female; Heart Valve Diseases - blood; Heart Valve Diseases - diagnosis; Heart Valve Diseases - epidemiology; Humans; Inflammation Mediators - blood; Lupus Erythematosus, Systemic - blood; Lupus Erythematosus, Systemic - diagnosis; Lupus Erythematosus, Systemic - epidemiology; Male; Pericarditis - blood; Pericarditis - diagnosis; Pericarditis - epidemiology; Prevalence; Retrospective Studies; Saudi Arabia - epidemiology
• ISSN: 0392-856X

To assess the prevalence and types of cardiovascular complications in Saudi patients with paediatric-onset systemic lupus erythematosus (pSLE). Retrospective record review of pSLE patients following from January 2014 to September 2015 at the rheumatology clinic of King Abdul-Aziz University Hospital, Jeddah. Laboratory data such as C-reactive protein (CRP), antinuclear antibodies (ANA), anti-double stranded DNA antibody (anti-dsDNA), C3 and C4 complements, were collected. Cardiac evaluation included chest x-ray, electrocardiogram (ECG), and echocardiography, along with estimation of SLE activity by calculating the SLE Disease Activity Index (SLEDAI) score according to SELENA modification. Forty-six cases of pSLE were included (91.3% females, mean±SD age at diagnosis=10.53±2.28 years). Prevalence of cardiac manifestations was 47.8%; the most frequent of which were valvular heart diseases diagnosed in 16 (34.8%) cases, followed by pericarditis in 6 (13%) cases. Of the 16 valvular diseases, tricuspid and pulmonary valves were involved in 9 and 8 cases, respectively. Cardiac involvement was silent in 36.4% and occurred as an initial presenting symptom of SLE in 9.1% cases. Biologically, patients with cardiac involvement had higher levels of CRP and anti dsDNA, and lower levels of complement C3 compared to patients with no cardiac involvement; while high SLE activity was the only significant predictor for cardiac involvement (beta=0.654; p=0.020). Cardiac complications are common in Saudi children with pSLE and are asymptomatic in 1 out of 3 times. They are predicted by high SLE activity and associate with high anti-dsDNA and CRP and low C3 levels.