Oral microbiota associated with hyposalivation of different origins

We analysed and compared the oral microbial flora in four groups with hyposalivation caused by radiation therapy (RT), primary Sjögren's syndrome (pSS), medication or unknown factors (Unknown), or neuroleptic treatment (Neuro). A control group with normal salivary secretion was also included. T...

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Published in:Oral microbiology and immunology 2003-02, Vol.18 (1), p.1-8
Main Authors: AlmståhI, A., Wikström, M., Stenberg, I., Jakobsson, A., Fagerberg-Mohlin, B.
Format: Article
Language:English
Subjects:
Analysis of Variance
Antipsychotic Agents - adverse effects
Biological and medical sciences
Candida albicans - isolation & purification
Colony Count, Microbial
Cranial Irradiation - adverse effects
Female
Fundamental and applied biological sciences. Psychology
Humans
hyposalivation
Lactobacillus - isolation & purification
Male
Microbiology
microflora
Middle Aged
saliva
Sjogren's Syndrome - complications
Statistics, Nonparametric
Streptococcus mutans - isolation & purification
Xerostomia - etiology
Xerostomia - microbiology
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Summary:We analysed and compared the oral microbial flora in four groups with hyposalivation caused by radiation therapy (RT), primary Sjögren's syndrome (pSS), medication or unknown factors (Unknown), or neuroleptic treatment (Neuro). A control group with normal salivary secretion was also included. The subjects included were 54 ± 8 years old and had 25 ± 4 teeth. We analysed their microflora in rinsing samples using a cultivation technique. A marked increase in Lactobacillus spp. and Candida albicans was characteristic of the RT group. In the pSS group, 85% of subjects had high numbers of mutans streptococci despite good oral hygiene, frequent dental visits and fluoride use. The Unknown group had an oral flora similar to that of the controls. In the Neuro group, with a stimulated secretion rate similar to that of the Unknown group, the numbers of aciduric and acidogenic microorganisms were close to those in the pSS group. The results indicate that changes in the oral microflora associated with hyposalivation are related to the reason for the hyposalivation rather than to the magnitude of the decrease in the salivary secretion rate.
ISSN:0902-0055
1399-302X
DOI:10.1034/j.1399-302X.2003.180101.x