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Two New Minor Polybrominated Dibenzo-p-dioxins from the Marine Sponge Dysidea dendyi

Two new minor tribromodibenzo-p-dioxins, spongiadioxin C (1) and its methyl ether (2), were isolated from an Australian marine sponge Dysidea dendyi, together with the known minor metabolites methyl ethers of spongiadioxins A (4) and B (6) and polybrominated diphenyl ethers (7−9). The structures of...

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Published in:	Journal of natural products (Washington, D.C.) D.C.), 2002-08, Vol.65 (8), p.1213-1215
Main Authors:	Utkina, Natalia K, Denisenko, Vladimir A, Virovaya, Marina V, Scholokova, Olga V, Prokof'eva, Nina G
Format:	Article
Language:	English
Subjects:	Animals Asteroidea Cell Division - drug effects Dioxins - chemistry Dioxins - isolation & purification Dioxins - pharmacology Dysidea dendyi Eggs Hydrocarbons, Brominated - chemistry Hydrocarbons, Brominated - isolation & purification Hydrocarbons, Brominated - pharmacology Inhibitory Concentration 50 Marine Methylation Molecular Structure natural products Nuclear Magnetic Resonance, Biomolecular Phenyl Ethers Porifera - chemistry Sea Urchins - drug effects Spectrometry, Mass, Electrospray Ionization spongiadioxin A spongiadioxin B spongiadioxin C
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description	Two new minor tribromodibenzo-p-dioxins, spongiadioxin C (1) and its methyl ether (2), were isolated from an Australian marine sponge Dysidea dendyi, together with the known minor metabolites methyl ethers of spongiadioxins A (4) and B (6) and polybrominated diphenyl ethers (7−9). The structures of the new compounds were established by 1D and 2D NMR spectroscopy and confirmed by synthesis of 2 from diphenyl ether 9. All isolated compounds inhibited the cell division of fertilized sea urchin eggs.
doi_str_mv	10.1021/np0106438
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source	American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list)
subjects	Animals Asteroidea Cell Division - drug effects Dioxins - chemistry Dioxins - isolation & purification Dioxins - pharmacology Dysidea dendyi Eggs Hydrocarbons, Brominated - chemistry Hydrocarbons, Brominated - isolation & purification Hydrocarbons, Brominated - pharmacology Inhibitory Concentration 50 Marine Methylation Molecular Structure natural products Nuclear Magnetic Resonance, Biomolecular Phenyl Ethers Porifera - chemistry Sea Urchins - drug effects Spectrometry, Mass, Electrospray Ionization spongiadioxin A spongiadioxin B spongiadioxin C
title	Two New Minor Polybrominated Dibenzo-p-dioxins from the Marine Sponge Dysidea dendyi
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