Cloning and characterization of ZAP36, an annexin-like, zymogen granule membrane associated protein, in exocrine pancreas

ZAP36, a zymogen granule membrane associated protein with 36 kDa, was cloned from both canine and rat pancreas. ZAP36 is found to be a novel member of annexin IV, and showed an apical localization in exocrine pancreas and an ubiquitous expression in epithelial tissues. ZAP36 may be involved in exocy...

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Bibliographic Details
Published in:Biochimica et biophysica acta 2002-05, Vol.1575 (1), p.148-152
Main Authors: Fukuoka, Shin-Ichi, Kern, Horst, Kazuki-Sugino, Reiko, Ikeda, Yoshiki
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Annexin
Annexin A4 - genetics
Annexin A4 - metabolism
Annexins - genetics
Annexins - metabolism
Apical localization
Base Sequence
Cytoplasmic Granules - metabolism
Dogs
Molecular cloning
Molecular Sequence Data
Northern blot
Pancreas
Pancreas - metabolism
Pancreas - ultrastructure
Rats
Sequence Alignment
Sequence Analysis, DNA
Zymogen granule
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Summary:ZAP36, a zymogen granule membrane associated protein with 36 kDa, was cloned from both canine and rat pancreas. ZAP36 is found to be a novel member of annexin IV, and showed an apical localization in exocrine pancreas and an ubiquitous expression in epithelial tissues. ZAP36 may be involved in exocytosis in apical regions of polarized cells.
ISSN:0167-4781
0006-3002
1879-2634
DOI:10.1016/S0167-4781(02)00299-3