Pediatric Epilepsy: Neurology, Functional Imaging, and Neurosurgery

• Published in: Seminars in nuclear medicine 2017-03, Vol.47 (2), p.170-187
• Main Authors: Mountz, James M., MD, PhD, Patterson, Christina M., MD, Tamber, Mandeep S., MD, PhD
• Format: Article
• Language: English
• Subjects: Child; Epilepsy - diagnostic imaging; Epilepsy - surgery; Functional Neuroimaging - methods; Humans; Neurology - methods; Neurosurgery - methods; Radiology
• ISSN: 0001-2998; 1558-4623
• DOI: 10.1053/j.semnuclmed.2016.10.003

In this chapter we provide a comprehensive review of the current role that functional imaging can have in the care of the pediatric epilepsy patient from the perspective of the epilepsy neurologist and the epilepsy neurosurgeon. In the neurology section, the diagnosis and classification of epilepsy adapted by the International League Against Epilepsy as well as the etiology and incidence of the disease is presented. The neuroimaging section describes how advanced nuclear medicine imaging methods can be synergized to provide a maximum opportunity to localize an epileptogenic focus. This section described the value of FDG-PET and regional cerebral blood flow SPECT in the identification of an epileptogenic focus. The imaging section also emphasizes the importance on developing a dedicated epilepsy management team, comprised of an epilepsy imaging specialist, epilepsy neurologist and epilepsy neurosurgeon, to provide the maximum benefit to each child with epilepsy. An emphasis is placed on preparation for ictal SPECT injection procedures, including the critical role of an automated injector well as the use of state-of-the-art dedicated nuclear medicine imaging and analysis protocols to correctly localize the epileptogenic focus location. In the final section, surgical options, approaches and expected outcomes for the different classes of epilepsy is presented.