Risk factors for visual field progression of normal-tension glaucoma in patients with myopia

• Published in: Canadian journal of ophthalmology 2017-02, Vol.52 (1), p.107-113
• Main Authors: Bae, Hyoung Won, MD, Seo, Sang Jin, MD, Lee, Sang Yeop, MD, Lee, Yun Ha, MD, Hong, Samin, MD, PhD, Seong, Gong Je, MD, PhD, Kim, Chan Yun, MD, PhD
• Format: Article
• Language: English
• Subjects: Adult; Aged; Disease Progression; Female; Follow-Up Studies; Humans; Internal Medicine; Low Tension Glaucoma - complications; Low Tension Glaucoma - diagnosis; Low Tension Glaucoma - physiopathology; Male; Middle Aged; Myopia - complications; Myopia - diagnosis; Myopia - physiopathology; Ophthalmology; Retinal Ganglion Cells - pathology; Retrospective Studies; Risk Factors; Scotoma - diagnosis; Scotoma - etiology; Scotoma - physiopathology; Time Factors; Tomography, Optical Coherence - methods; Visual Fields - physiology; Young Adult
• ISSN: 0008-4182; 1715-3360
• DOI: 10.1016/j.jcjo.2016.08.011

Abstract Objective To identify risk factors for visual field progression of normal-tension glaucoma (NTG) in patients with myopia. Design Longitudinal, observational study. Participants Fifty-one eyes of 51 NTG patients with myopia (less than −0.75D based on spherical equivalence) who had undergone visual field (VF) testing at least once per year for ≥6 years between November 2005 and December 2013. Methods Progression was defined using event-based guided progression analysis. Risk factors were analyzed using the Cox proportional hazards model and further tested for independence in a multivariate model. Results The mean observation period was 7.0 ± 1.3 years, and 16 of 51 subjects showed progression. In the univariate analysis, abnormal retinal nerve fibre layer (RNFL) colour codes (yellow or red sector) at the 11, 10, and 7 o’clock positions on optical coherence tomography showed significant associations with the VF progression ( p = 0.03, 0.03, and 0.01, respectively). In the final multivariate models, the abnormal RNFL colour code of the 7 o’clock sector (inferotemporal sector) was the only significant risk factor for progression (hazard ratio = 4.07 and 4.37; 95% CI, 1.11–14.92 and 1.27–15.04; p = 0.03 and 0.02, respectively). Conclusions Inferotemporal RNFL thinning could be a risk factor for progression in NTG patients with myopia.