N‑Heterocyclic Olefin Catalyzed Silylation and Hydrosilylation Reactions of Hydroxyl and Carbonyl Compounds

N-Heterocyclic olefins (NHOs), the alkylidene derivatives of N-heterocyclic carbenes (NHCs), have recently emerged as a new family of promising organocatalysts with strong nucleophilicity and Brønsted basicity. The development of a novel method is shown using NHOs as efficient promoters for the dire...

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Bibliographic Details
Published in:Organic letters 2017-03, Vol.19 (6), p.1398-1401
Main Authors: Kaya, Uǧur, Tran, Uyen P. N, Enders, Dieter, Ho, Junming, Nguyen, Thanh V
Format: Article
Language:English
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Summary:N-Heterocyclic olefins (NHOs), the alkylidene derivatives of N-heterocyclic carbenes (NHCs), have recently emerged as a new family of promising organocatalysts with strong nucleophilicity and Brønsted basicity. The development of a novel method is shown using NHOs as efficient promoters for the direct dehydrogenative silylation of alcohols or hydrosilylation of carbonyl compounds. Preliminary results of the first NHO-promoted asymmetric synthesis are also discussed.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.7b00306