Association of Disorganization of Retinal Inner Layers With Visual Acuity In Eyes with Uveitic Cystoid Macular Edema

Abstract Purpose To determine whether disorganization of retinal inner layers (DRIL) assessed by spectral domain optical coherence tomography (SD-OCT) correlates with visual acuity (VA) in eyes with uveitic cystoid macular edema (CME). Design Secondary analysis of Randomized Clinical Trial data. Met...

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Bibliographic Details
Published in:American journal of ophthalmology 2017-05, Vol.177, p.116-125
Main Authors: Grewal, Dilraj S., MD, O’Sullivan, Matthew L., PhD, Kron, Martina, PhD, Jaffe, Glenn J., MD
Format: Article
Language:English
Subjects:
Adalimumab - administration & dosage
Adult
Aged
Anti-Inflammatory Agents - administration & dosage
Diabetes
Diabetic retinopathy
Double-Blind Method
Edema
Female
Fluorescein Angiography
Fundus Oculi
Humans
Macular Edema - diagnosis
Macular Edema - etiology
Macular Edema - physiopathology
Male
Middle Aged
Neural networks
Ophthalmology
Pharmaceutical industry
Retina
Retina - pathology
Tomography
Tomography, Optical Coherence - methods
Uveitis - complications
Uveitis - diagnosis
Uveitis - drug therapy
Visual Acuity
Young Adult
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Summary:Abstract Purpose To determine whether disorganization of retinal inner layers (DRIL) assessed by spectral domain optical coherence tomography (SD-OCT) correlates with visual acuity (VA) in eyes with uveitic cystoid macular edema (CME). Design Secondary analysis of Randomized Clinical Trial data. Methods Fifty-six eyes of 42 patients with uveitic CME were prospectively imaged as part of the VISUAL-1 trial ( Clinicaltrials.gov identifier NCT01138657). Central subfield thickness (CFT), horizontal and vertical extent of DRIL, foveal DRIL (>500 μm DRIL) hyperreflective foci (HRF), average and largest area of intraretinal (IR) cysts, extent of disruption of external limiting membrane (ELM) and ellipsoid zone (EZ) were determined within the 1 mm central subfield, and correlated with VA at baseline and follow-up visits. Results Regression analysis adjusted for clustered observations was used to examine the association between OCT morphologic parameters and VA. Across all visits (n=168), significant associations were found for CFT (0.080 per 100 μm, p
ISSN:0002-9394
1879-1891
DOI:10.1016/j.ajo.2017.02.017