Significance of immune checkpoint proteins in EGFR -mutant non-small cell lung cancer

Highlights • Casesof advanced stage EGFR mutant NSCLC were analysed. • PD-L1, PD-1, CTLA-4 and TIM3 expression were characterized. • High tumor PD-L1 had a shorter PFS. • Immune cell CTLA-4 expression was prognostic.

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Bibliographic Details
Published in:Lung cancer (Amsterdam, Netherlands) Netherlands), 2017-03, Vol.105, p.17-22
Main Authors: Soo, Ross A, Kim, Hye Ryun, Asuncion, Bernadette Reyna, Fazreen, Zul, Omar, Mohamed Feroz Mohd, Herrera, Maria Cynthia, Yun Lim, Joey Sze, Sia, Grace, Soong, Richie, Cho, Byoung-Chul
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
B7-H1 Antigen - metabolism
Biomarkers, Tumor - metabolism
Carcinoma, Non-Small-Cell Lung - genetics
CD3 Complex - metabolism
CTLA-4 Antigen - metabolism
Cytotoxic T-lymphocyte antigen-4
Epidermal growth factor receptor mutations
Female
Hematology, Oncology and Palliative Medicine
Hepatitis A Virus Cellular Receptor 2 - metabolism
Humans
Lung Neoplasms - genetics
Male
Middle Aged
Mutation
Non-small cell lung cancer
Programmed Cell Death 1 Receptor - metabolism
Programmed death ligand-1
Protein Kinase Inhibitors - administration & dosage
Protein Kinase Inhibitors - therapeutic use
Pulmonary/Respiratory
Receptor, Epidermal Growth Factor - genetics
Survival Analysis
T-cell immunoglobulin and mucin-domain containing-3
Treatment Outcome
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Description
Summary:Highlights • Casesof advanced stage EGFR mutant NSCLC were analysed. • PD-L1, PD-1, CTLA-4 and TIM3 expression were characterized. • High tumor PD-L1 had a shorter PFS. • Immune cell CTLA-4 expression was prognostic.
ISSN:0169-5002
1872-8332
DOI:10.1016/j.lungcan.2017.01.008