Therapeutic journey of 2,4-thiazolidinediones as a versatile scaffold: An insight into structure activity relationship

Thiazolidinedione is an important heterocyclic ring system, a pharmacophore and a privileged scaffold in medicinal chemistry; is a derivative of thiazolidine ring which came into existence for its role as antihyperglycemic agent and a specific ligand of PPAR's (Peroxisome proliferator activated...

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Bibliographic Details
Published in:European journal of medicinal chemistry 2017-03, Vol.129, p.218-250
Main Authors: Naim, Mohd. Javed, Alam, Md. Jahangir, Ahmad, Shujauddin, Nawaz, Farah, Shrivastava, Neelima, Sahu, Meeta, Alam, Ozair
Format: Article
Language:English
Subjects:
Anticancer
Antihyperglycemic
Antimicrobial
Humans
Hypoglycemic Agents - chemistry
Hypoglycemic Agents - pharmacology
Peroxisome Proliferator-Activated Receptors - metabolism
PPARγ
Structure-Activity Relationship
Thiazolidinedione
Thiazolidinediones - chemistry
Thiazolidinediones - pharmacology
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Summary:Thiazolidinedione is an important heterocyclic ring system, a pharmacophore and a privileged scaffold in medicinal chemistry; is a derivative of thiazolidine ring which came into existence for its role as antihyperglycemic agent and a specific ligand of PPAR's (Peroxisome proliferator activated receptor). Exhaustive research has led to determination of its vast biological profile with wide range of therapeutic applications. This review covers recent pharmacological advancements of thiazolidinedione moiety along with structure activity relationship so as to provide better correlation among different structures and their receptor interactions. [Display omitted] •Thiazolidinediones are heterocyclic system consisting of 5 membered thiazolidine ring with carbonyl groups at 2 & 4 position.•The position 2 of thiazolidinedione is the most suitable position to carry out substitution reactions.•Being a promising scaffold; it exhibits wide range of biological activities.
ISSN:0223-5234
1768-3254
DOI:10.1016/j.ejmech.2017.02.031