Predictors of curative resection and long term survival of gallbladder cancer – A retrospective analysis

Abstract Background Gallbladder cancer (GBC) is an aggressive malignancy. We analysed factors predicting resectability and survival of patients with GBC and the impact of surgical obstructive jaundice (SOJ). Methods Four hundred and thirty-seven patients with suspected GBC were analysed (52 excluded...

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Bibliographic Details
Published in:The American journal of surgery 2017-08, Vol.214 (2), p.278-286
Main Authors: Mishra, Pramod Kumar, Saluja, Sundeep Singh, Prithiviraj, Nabi, Varshney, Vaibhav, Goel, Neeraj, Patil, Nilesh
Format: Article
Language:English
Subjects:
Abdomen
Adolescent
Adult
Aged
Aged, 80 and over
Benign
Bile
Biopsy
Cancer
Carcinoma gallbladder
Endoscopy
Female
Gallbladder
Gallbladder cancer
Gallbladder Neoplasms - complications
Gallbladder Neoplasms - mortality
Gallbladder Neoplasms - surgery
Humans
Infiltration
Jaundice
Jaundice, Obstructive - etiology
Jaundice, Obstructive - mortality
Jaundice, Obstructive - surgery
Laparoscopy
Liver
Lymphatic system
Male
Malignancy
Medical prognosis
Metastases
Metastasis
Middle Aged
Morbidity
Mortality
Patients
Predictors of resectability
Prognosis
Radical cholecystectomy
Remission Induction
Resectability in gallbladder cancer
Retrospective Studies
Subgroups
Surgery
Surgical obstructive jaundice
Surgical outcomes
Survival
Survival Rate
Time Factors
Ultrasonic imaging
Weight loss
Young Adult
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Summary:Abstract Background Gallbladder cancer (GBC) is an aggressive malignancy. We analysed factors predicting resectability and survival of patients with GBC and the impact of surgical obstructive jaundice (SOJ). Methods Four hundred and thirty-seven patients with suspected GBC were analysed (52 excluded: benign pathology n = 35, missed GBC n = 17). The remaining 385 patients were divided into non-SOJ (n = 234) and SOJ (n = 151) groups. Predictors of resectability and long term survival were analysed and compared with their subgroups. Results Patients with gastric outlet obstruction, abdominal lump, weight loss and SOJ were more likely to be unresectable (p:0.04, 0.024, 0.003 and 0.003, respectively). TNM stage, node positivity and adjacent organ involvement were predictors of survival (p 
ISSN:0002-9610
1879-1883
DOI:10.1016/j.amjsurg.2017.02.006